Day: September 10, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.578743-87-0,[1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride,as a common compound, the synthetic route is as follows.,578743-87-0

Chloro[l,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I) (195.1 mg, 0.4 mmol) and silver triflate (102.7 mg, 0.4 mmol) were mixed under nitrogen in 25 mL flask and 10 mL of dry THF were added. Reaction mixture was stirred at RT for 30 minutes.Solution of 2,2′-bipyridine (62.4 mg, 0.4 mmol) in dry THF (5 mL) was added. Reaction mixture turned orange and was stirred at RT overnight. Resulting mixture was filtered through Celite and solvent was evaporated on rotovap. Recrystallization from CH2CI2 by vapor diffusion of EtaO gave 215 mg (70.9%) of orange crystals. Anal, calcd. forC38H44CUF3N4O3S: C, 60.26; H, 5.86; N, 7.40; Found: C, 60.18; H, 5.82; N, 7.38. Structure was confirmed by iH-NMR spectrum of [(IPR)Cu(bipy)]OTf (CDCb, 400MHz).

As the paragraph descriping shows that 578743-87-0 is playing an increasingly important role.

Reference£º
Patent; THE UNIVERSITY OF SOUTHERN CALIFORNIA; THOMPSON, Mark; DJUROVICH, Peter; KRYLOVA, Valentina; WO2011/63083; (2011); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

578743-87-0, [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride is a copper-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,578743-87-0

In a dry double-mouth bottle to place Pt – 1 (0.0544 g, 0.1 mmol), CuClNHC (0.0488 g, 0.1 mmol), vacuum pumping and nitrogen cycle three times, then the nitrogen flow by adding 10 ml ethanol, stirring reflux reaction for 4 hours, cooling to room temperature, then added potassium hexafluorophosphate (0.184 g, 1 mmol), stirring at the room temperature reaction 2 hours, filtered, concentrated filtrate, ethanol: dichloromethane=1:10 column, get the orange solid 0.045 g, and the yield is 40%.

The synthetic route of 578743-87-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Jiangsu University Of Science And Technology; Shi Chao; Li Qiuxia; Zhang Xinghua; (24 pag.)CN108690096; (2018); A;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belongs to copper-catalyst compound, name is [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride, and cas is 578743-87-0, its synthesis route is as follows.,578743-87-0

In a flame-dried Schlenk tube under argon atmosphere, [CuCl(IPr)] (1) (0.3mmol, 150mg, 1 equiv.) and KCN (0.3mmol, 19mg, 1 equiv.) were introduced in degassed MeOH (5mL) and the reaction mixture was stirred under reflux (50C) for 4h. After returning to room temperature, the reaction mixture was concentrated to dryness under vacuum. The complex was then dissolved in dichloromethane and filtered through a pad of Celite and concentrated again under vacuum. A purification by recrystallization by slow diffusion of pentane in a THF solution of the complex led to the pure complex (4) as a white powder (143mg, 97% yield). 1H-NMR (CDCl3, 400MHz): delta 1.22 (d, J=6.9Hz, 12H), 1.27 (d, J=6.9Hz, 12H), 2.50 (sept, J=6.9Hz, 4H), 7.14 (s, 2H), 7.30 (d, J=7.8Hz, 4H), 7.50 (t, J=7.8Hz, 4H) ppm. (spectroscopic data in good agreement with the literature) [54].

With the complex challenges of chemical substances, we look forward to future research findings about [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride

Reference£º
Article; Elie, Margaux; Mahoro, Gilbert Umuhire; Duverger, Eric; Renaud, Jean-Luc; Daniellou, Richard; Gaillard, Sylvain; Journal of Organometallic Chemistry; vol. 893; (2019); p. 21 – 31;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belongs to copper-catalyst compound, name is [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride, and cas is 578743-87-0, its synthesis route is as follows.,578743-87-0

Chloro[l ,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I) (487.59 mg, 0.25 mmol) and silver triflate (64.2 mg, 0.25 mmol) were mixed under nitrogen in 25 mL flask and 10 mL of dry THF were added. Reaction mixture was stirred at RT for 30 minutes. Solution of 1 ,2-bis(diphenylphosphino)benzene (1 1 1.6 mg, 0.25 mmol) in dry THF (5 mL) was added. Reaction mixture was stirred at RT overnight. Resulting mixture was filtered through Celite and solvent was evaporated on rotovap. Recrystallization from CH2CI2 by vapor diffusion of Et20 gave 130 mg (49.6%) of white needle crystals. Structure confirmed by 1H-NMR spectrum of [(IPR)Cu(dppbz)]OTf (CDCb, 400MHz).

With the complex challenges of chemical substances, we look forward to future research findings about [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride

Reference£º
Patent; THE UNIVERSITY OF SOUTHERN CALIFORNIA; THOMPSON, Mark; DJUROVICH, Peter; KRYLOVA, Valentina; WO2011/63083; (2011); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO350,mainly used in chemical industry, its synthesis route is as follows.,34946-82-2

Was added to the Schlenk tube Cu(OTf)2 (0.01mmol), ligand (Ra,S,S)-I-Ph (0.01mmol) N2 protection, the solvent was added CHCl3(2 mL), stirred at room temperature for 4 hours ligand, and concentrated under reduced pressure, vacuum drained, i.e., quantitative complex to give [(Ra,S,S)-I-Ph]Cu(OTf)2.

With the synthetic route has been constantly updated, we look forward to future research findings about Copper(II) trifluoromethanesulfonate,belong copper-catalyst compound

Reference£º
Patent; Zhejiang University; Lin Xufeng; Gu Haorui; Sun Weiye; (21 pag.)CN108794420; (2018); A;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO380,mainly used in chemical industry, its synthesis route is as follows.,7787-70-4

A yellow solution of 168.0 mg (0.736 mmol) of 2b in toluene (10 mL) was added to a green CH3CN solution (20 mL) containing 105.6 mg (0.736 mmol) CuBr with stirring at ambient temperature. The reaction mixture was allowed to stir overnight forming a dark green precipitate. The solution was filtered, and the precipitate washed with cold MeOH (5 mL) and dried under vacuum (57.9 mg, 17% yield). 1H and 13C{1H} NMR spectra could not be recorded due to strong paramagnetic properties of complex. FTIR (KBr) 3425, 3056, 3006, 2918, 1627, 1593, 1466, 1436, 1300, 1269, 1236, 1201, 1157, 1106, 1092, 1069, 1046, 967, 958, 914, 849, 774, 767, 744, 694, 652, 567, 543, 501, 458, 417 cm-1. Anal. Calc’d. for C13H12Br2CuN2S: C = 34.57%, H = 2.68%, N = 6.20%. Found: C = 34.17%, H = 3.36%, N = 6.44%. UV-vis (DMF, 0.050 mg/mL) lambdamax (epsilon) = 266 (7.6 * 103), 353.

With the synthetic route has been constantly updated, we look forward to future research findings about Copper(I) bromide,belong copper-catalyst compound

Reference£º
Article; Cross, Edward D.; Ang, M. Trisha C.; Richards, D. Douglas; Clemens, Amy C.; Muthukumar, Harshiny; McDonald, Robert; Woodfolk, London; Ckless, Karina; Bierenstiel, Matthias; Inorganica Chimica Acta; vol. 481; (2018); p. 69 – 78;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

7787-70-4,7787-70-4, Copper(I) bromide is a copper-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Triethyl phosphite (183g, 1.1 mol) was added to a suspension of copper(I) bromide (164.5 g, 1.15 mol) in toluene (500 ml). The mixture was heated at 80C for 3 h with stirring, then left to cool and settle. The clear solution was decanted from the solid residue and the solvent evaporated on a rotary evaporator at 60C, to provide copper(I) bromide triethyl phosphite complex as a clear colourless oil, 336g (94% crude yield).

The synthetic route of 7787-70-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/67412; (2006); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34946-82-2,Copper(II) trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.

General procedure: A mixture of ligand L (23.1 mg, 55 mumol) and appropriate metalsalt (55 mumol) in nitromethane (20 mL) was stirred at room temperaturefor 48 h under the normal atmosphere. The complexeswere isolated as a solids by evaporation of the solvent and followedby a dissolution of the residue in the minimum volume of CH3CNand precipitation of the complexes by the gradual addition ofether. Obtained solids were filtered off and dried in air., 34946-82-2

As the paragraph descriping shows that 34946-82-2 is playing an increasingly important role.

Reference£º
Article; Wa??sa-Chorab, Monika; Marcinkowski, Dawid; Kubicki, Maciej; Hnatejko, Zbigniew; Patroniak, Violetta; Polyhedron; vol. 118; (2016); p. 1 – 5;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belong copper-catalyst compound,Copper(II) trifluoromethanesulfonate,34946-82-2,Molecular formula: C2CuF6O6S2,mainly used in chemical industry, its synthesis route is as follows.,34946-82-2

The ligand (75.9 mg, 0.12 mmol) was dissolved in THF (4 ml) and added to a suspension of sodium hydride (11.8 mg, 0.49 mmol) in THF (2 ml) at 0 C. The resulting yellow mixture was stirred at 0 C for 1 h and at r. t. for 2 h. Afterwards the solution was added dropwise to a solution of copper(II) triflate (44.3 mg, 0.12 mmol) in THF (2 ml). The dark brown solution was stirred at r. t. for 16 h. After filtration the solvent was removed in vacuo and the brown solid purified by recrystallisation from dichloromethane and pentane. 6: 60.8 mg, 60.9%. C41H36N5O5SF3Cu¡¤3CH2Cl2: Anal. Calc. C, 46.35; H, 4.24; N, 6.14. Found: C, 46.70; H, 4.12; N, 6.19%. HR-MS: C40H36N5O2Cu Calc. 681.2159. Found: 681.2148 (100.0), IR: nunu [cm-1]=3060, 2929, 2855, 1640, 1592, 1530, 1444, 1262, 1174, 1097, 1044, 879, 646.

With the synthetic route has been constantly updated, we look forward to future research findings about Copper(II) trifluoromethanesulfonate,belong copper-catalyst compound

Reference£º
Article; Sauer, Desiree C.; Wadepohl, Hubert; Polyhedron; vol. 81; (2014); p. 180 – 187;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belong copper-catalyst compound,Copper(I) bromide,7787-70-4,Molecular formula: BrCu,mainly used in chemical industry, its synthesis route is as follows.,7787-70-4

General procedure: A suspension of copper(I) iodide (0.190 g, 1.0 mmol) and dppc (0.534 g, 1.0 mmol) in20 mL of CH2Cl2 was stirred for 6 h at room temperature to form a light-yellow precipitate.The precipitate was filtered off and purified by recrystallization from CH2Cl2/ethanolto give yellow crystals (Yield: 0.618 g, 85.3%).

With the synthetic route has been constantly updated, we look forward to future research findings about Copper(I) bromide,belong copper-catalyst compound

Reference£º
Article; Li, Qian; Wei, Qiong; Xie, Pei; Liu, Li; Zhong, Xin-Xin; Li, Fa-Bao; Zhu, Nian-Yong; Wong, Wai-Yeung; Chan, Wesley Ting-Kwok; Qin, Hai-Mei; Alharbi, Njud S.; Journal of Coordination Chemistry; vol. 71; 24; (2018); p. 4072 – 4085;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”