Day: September 15, 2020

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO258,mainly used in chemical industry, its synthesis route is as follows.,34946-82-2

A solution of imidazo[l,2-b]pyridazine (impy) (758 mg, 6.36 mmol, 10 equiv.) in MeOH (1 mL) was added dropwise at 55C to a solution of Cu(OTf)2 (230 mg, 0.636 mmol, 1.0 equiv.) in MeOH (1 mL). The blue precipitate which formed was washed with Et20 (3 x 2 mL), then recrystallized from hot MeOH to afford [Cu(OTf)2(impy)4] (324 mg, 0.387 mmol. 61%). Anal. Calcd. for C26H2OCUF6NI206S2: C, 37.26; H, 2.41; N, 20.05. Found: C, 37.07; H, 2.33; N, 19.91; IR (ATR, neat): v (cm 1) = 2981, 1620, 1541, 1503, 1374, 1352, 1306, 1281, 1241, 1221, 1149, 1071, 1027, 950, 918, 879, 801, 755, 733, 632.

With the synthetic route has been constantly updated, we look forward to future research findings about Copper(II) trifluoromethanesulfonate,belong copper-catalyst compound

Reference£º
Patent; OXFORD UNIVERSITY INNOVATION LIMITED; GOUVERNEUR, Veronique; CORNELISSEN, Bart; WILSON, Thomas Charles; (152 pag.)WO2019/186135; (2019); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO365,mainly used in chemical industry, its synthesis route is as follows.,7787-70-4

A solution of (4-diphenylphosphino)phenanthridine (0.023 g,0.063 mmol) in CH2Cl2 (3 mL) was added drop-wise to a suspensionof CuBr (0.089 g, 0.063 mmol) in CH2Cl2 (3 mL) with constantstirring. The reaction mixture was stirred for overnight at roomtemperature. Then the reaction mixture was filtered through smallplug of Celite and dried under vacuum to give an orange solid.Yield = 0.022 g (71%).

With the synthetic route has been constantly updated, we look forward to future research findings about Copper(I) bromide,belong copper-catalyst compound

Reference£º
Article; Mondal, Rajarshi; Giesbrecht, Patrick K.; Herbert, David E.; Polyhedron; vol. 108; (2016); p. 156 – 162;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO442,mainly used in chemical industry, its synthesis route is as follows.,7787-70-4

a. 2-(carboxy-5-nitro-phenyl)malonic acid dimethyl ester (2) A solution of 2-chloro-4-nitrobenzoic acid (75 g, 372 mmol) in dimethyl malonate (900 mL) was sparged with nitrogen for 15 min. Sodium methoxide (48.3 g, 894 mmol) was added in one portion and the contents exothermed to 480 C. Fifteen minutes later, copper (I) bromide (5.4 g, 37 mmol) was added in one portion and the contents heated to 70 C. for 24 hrs. The reaction was 70% complete by nmr, the contents heated to 85 C. for 6 hrs to completely consume the 2-chloro-4-nitrobenzoic. Water (900 mL) was added to the cooled reaction followed by hexanes (900 mL). The aqueous layer was separated, toluene (900 mL) added, filtered through celite, and aqueous layer separated. Fresh toluene (1800 mL) was added to the aqueous layer and the biphasic mixture acidified with 6N aqueous HCl (90 mL). A white precipitate formed and the contents stirred for 18 hrs. The product was filtered off and dried to give a white soid (78.1 g, 70%) mp=153 C. 1 H NMR (CD3)2 SO delta 78.37 (d, J=2 Hz, 1H), 8.30 (d, J=1 Hz, 2H), 5.82 (s, 1H), (3.83 (s, 6H). 13 C NMR (CD3)2 SO delta 168.0, 167.3, 149.4, 137.1, 135.8, 132.5, 125.4, 123.7, 54.5, 53.4. Anal. Calcd for C11 H10 NO8: C, 48.49; H, 3.73; N, 4.71. Found: C, 48.27; H. 3.72; N, 4.76.

With the synthetic route has been constantly updated, we look forward to future research findings about Copper(I) bromide,belong copper-catalyst compound

Reference£º
Patent; Pfizer INc.; US5919795; (1999); A;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belong copper-catalyst compound,Copper(II) trifluoromethanesulfonate,34946-82-2,Molecular formula: C2CuF6O6S2,mainly used in chemical industry, its synthesis route is as follows.,34946-82-2

A mixture of Cu(CF3SO3)2 (200 mg, 0.55 mmol) and ligand L(190 mg, 0.55 mmol) in a mixture of MeOH:CH2Cl2 in 1:1 volumeratio (30 mL) was stirred at room temperature for 24 h. The productwas isolated by evaporation of solvents and recrystallization of the residuefrom a minimum volume of MeOH by the gradual addition ofdiethyl ether to obtain complex 5 as a green solid. Crystal appropriatefor X-ray diffraction was obtained by vial to vial diffusion at 4 C.Yield: 80.3% (335 mg, 0.44 mmol).ESI-MS: m/z (%) = 345 [H + L]+ (100), 407 [Cu(L-H)]+ (90). IR(KBr): nu(CH)ar 3053; nuas(CH3) 2972; nus(CH3) 2877; nu(C=N)imin1553; nu(C=C)ar 1581, 1547, 1525, nu(CN) 1488, 1422; nu(C=N)ar1279, 1235, rho(CH)ar 1187, 1172, 1137; gamma(CH)ar 891, 782, 723,551 cm-1. Anal. calc. for [Cu(C20H16N4S)(CF3SO3)(MeOH)(H2O)](CF3SO3)] (756.17): C, 36.53; H, 2.93; N, 7.41; Found: C, 36.40; H, 2.99;N, 7.35%.

With the synthetic route has been constantly updated, we look forward to future research findings about Copper(II) trifluoromethanesulfonate,belong copper-catalyst compound

Reference£º
Article; Bocian, Aleksandra; Gorczy?ski, Adam; Marcinkowski, Damian; Witomska, Samanta; Kubicki, Maciej; Mech, Paulina; Bogunia, Ma?gorzata; Brzeski, Jakub; Makowski, Mariusz; Pawlu?, Piotr; Patroniak, Violetta; Journal of Molecular Liquids; vol. 302; (2020);,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7787-70-4,Copper(I) bromide,as a common compound, the synthetic route is as follows.

7787-70-4, A mixture of PLN(37.6 mg, 0.2 mmol) containing CH3ONa (11.8 mg, 0.22 mmol) andCuBr (22 mg, 0.2 mmol) in methanolic solution (10 mL) was refluxed for 2 h, followed by addition of 1,10-phenanthroline (36 mg,0.2 mmol) in methanol (10 mL). The mixture was stirred for another 30 min at room temperature to give a dark-red solution and then filtered.The filtrate was kept in air for a week, forming dark-red block crystals. The crystals were isolated, washed three times with distilled water and dried in a vacuum desiccator containing anhydrous CaCl2. Yield: 87.9 mg (81%). Anal. Calcd for C24H19BrCuN2O4 (542.86): C,53.10; H, 3.52 and N, 5.16. Found: C, 53.12; H, 3.53 and N, 5.17. IR(KBr, cm-1): 3500, 3041, 1986, 1837, 1628, 1590, 1568, 1510, 1418,1344, 1196, 1159, 1106, 993, 855, 773, 720, 672, 631, 551, 548, 528,468, 455, 430.

The synthetic route of 7787-70-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gou, Yi; Zhang, Zhan; Qi, Jinxu; Liang, Shichu; Zhou, Zuping; Yang, Feng; Liang, Hong; Journal of Inorganic Biochemistry; vol. 153; (2015); p. 13 – 22;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34946-82-2,Copper(II) trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.

General procedure: To a light blue aqueous solution (4 mL) of Him(5.5 mg, 0.081 mmol) and Cu(BF4)26H2O (28 mg, 0.081 mmol)was added methanol solution (4 mL) of pz3CH (17 mg,0.079 mmol), and then 5v/v% TEA methanol solution (0.5 mL).The mixed solution was gently warmed for 1 h. After standing fora few days, a mixture of dark green crystals (a major product)and a light blue precipitate (a minor product) was formed. The darkgreen crystals were carefully separated from the mixture under amicroscope., 34946-82-2

As the paragraph descriping shows that 34946-82-2 is playing an increasingly important role.

Reference£º
Article; Kogane, Tamizo; Ondo, Akihiro; Yamasaki, Masaru; Kanetomo, Takuya; Ishida, Takayuki; Polyhedron; vol. 136; (2017); p. 64 – 69;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

34946-82-2, Copper(II) trifluoromethanesulfonate is a copper-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

For the synthesis of (II), a solution of BDPA (0.160 g,0.265 mmol) in THF (5.0 ml) was added to a solution ofCu(triflate)2 (0.095 g, 0.265 mmol) in THF (3.0 ml) under aninert atmosphere and this mixture was stirred for 12 h. The resulting blue solution was diffused with diethyl ether, yielding blue block-shaped crystals after 3 d (yield: 0.110 g, 44%).Elemental analysis calculated: C 38.74, H 2.94, N 6.45, S9.85%; found: C 38.79, H 2.98, N 6.52, S 9.90%. FT-IR (KBr,cm-1); 2980 (w), 2927 (m), 1620 (m), 1455 (m), 1307 (m),1275 (s), 1215 (s), 1155 (s), 1029 (s), 922 (w), 849 (s), 790 (m),770 (m), 737 (m), 697 (s).

34946-82-2, As the paragraph descriping shows that 34946-82-2 is playing an increasingly important role.

Reference£º
Article; Sivanesan, Dharmalingam; Youn, Min Hye; Park, Ki Tae; Kim, Hak Joo; Grace, Andrews Nirmala; Jeong, Soon Kwan; Acta Crystallographica Section C: Structural Chemistry; vol. 73; 11; (2017); p. 1024 – 1029;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

34946-82-2, Copper(II) trifluoromethanesulfonate is a copper-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of Cu(OTf )2 (0.089 g, 0.25 mmol) in 1 mL of CH3CN was added to a stirred solution of 2-pina (0.050 g, 0.25 mmol) in 1 mL of CH3CN. The blue suspension was stirred for 1.5 h and the solvent was removed under reduced pressure. The resulting blue solid was washed with Et2O (5 mL ¡Á 3). Dissolving the product in DMF and vapor diffusion of Et2O into the blue solution at room temperature led to green crystals suitable for X-ray crystallographic characterization (0.095 g, 54% yield). Anal. Calcd for C19H23N5O9F6S2Cu: C, 32.28; H, 3.28; N, 9.90. Found: C, 31.96; H, 3.03; N, 10.15. FT-IR (cm-1): 1644, 1619, 1546, 1457, 1431, 1386, 1369, 1243, 1223, 1147, 1106, 1028, 862, 759, 698, 667, 634, 572, 516, 418., 34946-82-2

As the paragraph descriping shows that 34946-82-2 is playing an increasingly important role.

Reference£º
Article; McMoran, Ethan P.; Mugenzi, Clement; Fournier, Kyle; Draganjac, Mark; Tony, Donavon; Jeong, Kwangkook; Powell, Douglas R.; Yang, Lei; Journal of Coordination Chemistry; vol. 69; 3; (2016); p. 375 – 388;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7787-70-4,Copper(I) bromide,as a common compound, the synthetic route is as follows.

7787-70-4, a. 2-(carboxy-5-nitro-phenyl)malonic acid dimethyl ester (2) A solution of 2-chloro-4-nitrobenzoic acid (75g, 372mmol) in dimethyl malonate (900mL) was sparged with nitrogen for 15 min. Sodium methoxide (48.3g, 894mmol) was added in one portion and the contents exothermed to 48C. Fifteen minutes later, copper (I) bromide (5.4g, 37mmol) was added in one portion and the contents heated to 70C for 24 hrs. The reaction was 70% complete by nmr, the contents heated to 85C for 5 hrs to completely consume the 2-chloro-4-nitrobenzoic. Water (900mL) was added to the cooled reaction followed by hexanes (900mL). The aqueous layer was separated, toluene (900mL) added, filtered through celite, and aqueous layer separated. Fresh toluene (1800mL) was added to the aqueous layer and the biphasic mixture acidified with 6N aqueous HCl (90mL). A white precipitate formed and the contents stirred for 18 hrs. The product was filtered off and dried to give a white solid (78.1g, 70%) mp=153C. 1H NMR (CD3)2SO delta 8.37 (d, J = 2 Hz, 1H), 8.30 (d, J = 1Hz, 2H), 5.82 (s, 1H), 3.83 (s, 6H). 13C NMR (CD3)2SO delta 168.0, 167.3, 149.4, 137.1, 135.8, 132.5, 125.4, 123.7, 54.5, 53.4. Anal. Calcd for C11H10NO8: C, 48.49; H, 3.73; N, 4.71. Found: C, 48.27; H, 3.72; N, 4.76.

The synthetic route of 7787-70-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER INC.; EP1181954; (2002); A2;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

7787-70-4,7787-70-4, Copper(I) bromide is a copper-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: CuI (0.095 g, 0.05 mmol) and PPh3 (0.262 g, 0.10 mmol) in 10 ml of MeCN were stirred for 1 h at 80 C to get a clear solution. To the reaction mixture, a solution of Hnor (0.082 g, 0.05 mmol) in methanol (5 mL) was added dropwise and left on stirring for 4 h. Then the mixture was filtered, and a colorless clear solution was obtained, which was left for slow evaporation leading to crystallization at room temperature. After a few days white crystals were obtained that were suitable for a single-crystal X-ray diffraction analysis.

7787-70-4 Copper(I) bromide 24593, acopper-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Khan, Rais Ahmad; Dielmann, Fabian; Liu, Xue; Hahn, F. Ekkehardt; Al-Farhan, Khalid; Alsalme, Ali; Reedijk, Jan; Polyhedron; vol. 111; (2016); p. 173 – 178;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”