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Dibenzo[b,d]thiopyran derivatives, pharmaceutical composition and use

The invention relates to compounds having the general formula (I) STR1 wherein R1 is carboxy, esterified carboxy or an amide of formula STR2 in which R9 is hydrogen or C1 -C6 alkyl, A is C2 -C6 alkylene and Ra and Rb are hydrogen or C1 -C6 alkyl or Ra and Rb taken together with the nitrogen atom to which they are linked form a saturated, optionally substituted, heteromonocyclic ring; R2 is hydrogen or C1 -C6 alkyl; each of R3 to R8 is independently hydrogen, halogen, C1 -C6 -alkyl, C3 -C4 alkenyloxy or C1 -C6 alkoxy; and the pharmaceutically acceptable salts thereof, which are useful as immunomodulating and anti-viral agents.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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Synthesis, crystal structures and third-order nonlinear optical properties of a new family of double incomplete cubane-like clusters [(eta5-C5Me5)2Mo 2(mu3-S)3SCu2X(mu-X)] 2(X = Cl-, Br-, SCN-) and cubane-like clusters […].

Reactions of trans-[(eta5-C5Me5)2Mo 2(mu-S)2S2] (1) with 2 equiv. of CuX (X = Cl-, Br-, SCN-, CN-) in refluxing acetonitrile resulted in a new set of Mo/Cu/S cluster compounds [(eta5-C5Me5)2Mo 2(mu3-S)3SCu2Cl(mu-Cl)] 2 (2), [(eta5-C5Me5)2Mo 2(mu3-S)4(CuBr)2] (3) and [(eta5-C5Me5)2Mo 2(mu3-S)3SCu2Br(mu-Br)] 2 (4), [(eta5-C5Me5)2Mo 2(mu3-S)4(CuSCN)2] (5) and [(eta5-C5Me5)2Mo 2(mu3-S)3SCu2(SCN)(mu-SCN)] 2 (6) and [(eta5-C5Me5)2Mo 2(mu3-S)4(CuCN)2] (7). Compounds 2-7 were fully characterized by elemental analysis, IR, UV-Vis, 1H NMR and single-crystal X-ray crystallography. Compounds 2, 4 and 6 consist of two incomplete cubane-like [(eta5-C5Me5)2Mo 2(mu3-S)3SCu2X] species bridged by a pair of mu-X- anions while 3, 5 and 7 contain a cubane-like [(eta5-C5Me5)2Mo 2(mu3-S)4Cu2] core with each of two terminal X- coordinated at each copper(I) center. The third-order nonlinear optical (NLO) properties of 2-5 and 7 along with [(eta5-C5Me5)2Mo 2(mu3-S)4(CuCl)2] in CH2Cl2 were investigated by using Z-scan technique at 532 nm. All these clusters showed strong third-order NLO absorption effects and self-defocusing properties.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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Method of treating estrogen dependent cancers

A method for alleviating the symptoms of post-menopausal syndrome comprising administering to a woman in need thereof an effective amount of a compound of formula I STR1 wherein R1a is –H or –OR7a in which R7a is –H or a hydroxy protecting group; R2a is –H, halo, or –OR8a in which R8a is –H or a hydroxy protecting group; R3 is 1-piperidinyl, 1-pyrrolidino, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; n is 2 or 3; and Z is –O– or –S–; or a pharmaceutically acceptable salt thereof.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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FILM

The object of the present invention is to provide a polydialkylsiloxane backbone containing film excellent in durability against hot water. The film of the present invention comprises a polydialkylsiloxane backbone, wherein the ratio of carbon atoms to silicon atoms (C/Si) is not less than 0.93 and less than 1.38 in terms of moles. In the film, the magnitude of a contact angle change ratio dW represented by a specific formula can be not less than ?10% provided that theta0 is an initial contact angle of water, and thetaW is a contact angle of water on the film immersed in ion-exchanged water of 70 C. for 24 hours.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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Structural chemistry of thiocyanatometallates. Crystal structures of Ph4PCu(SCN)2 and (PPN)Cu(SCN)2

Colourless columnar crystals of Ph4PCu(SCN)2 (1) were obtained by reaction of CuSCN with Ph4PSCN in acetone. 1 crystallises in the orthorhombic space group P212121 with a = 746.50(10); b = 1623.8(3); c = 1999.4(4) pm; Z = 4; V = 2423.6(7) · 106 pm3. Colourless lamella shaped crystals of (PPN)Cu(SCN)2 (2) were formed by reactions of (PPN)CuCl2 with KSCN in ethanol. 2 crystallises in the triclinic space group P1 with a = 1101.3(2); b = 1141.6(2); c = 1522.9(3) pm; alpha = 74.75(3); beta = 80.50(3); gamma = 70.74(3); Z = 2; V = 1737.4(6) · 106 pm3. In both compounds the anions consist of approximately planar groups with Cu atoms co-ordinated by two N and one S atom. In each case one SCN is a N-bound terminal group while the second SCN forms a 1,3-mu bridge between two Cu centres. In 1 the planar CuN2S units are connected to polymer anions with chain structure, whereas 2 contains dimeric anions [SCNCu(SCN)2CuNCS].

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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METAL-BASED HYDROGEN SULFIDE SCAVENGER AND METHOD OF PREPARING SAME

The present disclosure is related to a family of oil-based dispersions of organic and inorganic metal compounds for use as a hydrogen sulfide scavenger in asphalt, and the preparation thereof. These dispersions comprise organic and inorganic metal compounds, organic solvents, an organoclay suspension agent, an emulsifier and optionally a polymeric stabilizer. The organic and inorganic metal compounds are in the form of micron-sized particles. Copper-based dispersions are particularly effective at reducing the hydrogen sulfide emission of asphalt in the presence of polyphosphoric acid.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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Electrodeposition of CuSCN seed layers and nanowires: A microelectrogravimetric approach

This paper analyzes the microelectrogravimetric aspects of CuSCN electrochemical deposition. Samples were prepared under conditions typically used during the first preparation step of the increasingly developed inverted photovoltaic cells, i.e., an approach based on the deposition of a hole transporting layer (p-type semiconductor) as a starting film. Here, both CuSCN seed layers and nanowires are the result of an electrodepositon process that uses electrolytes rich in Cu(II) species, thiocyanate ions and additives such as triethanolamine (TEA) or ethylenediaminetetraacetic acid (EDTA). Gold (Au) reactivity was compared to that of Indium Tin Oxide (ITO) coated quartz electrodes in the presence of aqueous thiocyanate ions. Consequently, ITO was confirmed as a suitable substrate for microelectrogravimetric purposes under conditions in which gold becomes electrochemically corroded. Both the speciation and the solubility diagrams for Cu(II) were prepared considering the presence of either TEA or EDTA as additives to establish the possible electroactive species involved in the electrochemical formation of CuSCN and its solubility as it grows. Following a potentiodynamic study and regardless of the additive used, it can be stated that CuSCN is accumulated on the electrode and is then reoxidized. The latter is accompanied by an almost complete loss of the previously accumulated mass. During the elapsed time of the experiments, two Cu(II) insoluble species, namely Cu(SCN)TEA and Cu(SCN)2, were stabilized as colloids in the employed electrolytes. These colloids can also participate as electroactive species in the CuSCN electroformation. However, for a better interpretation of results, more complete speciation diagrams are also required, but thermodynamic information on these species is still not available. During both potentiostatic and galvanostatic CuSCN growth, a CuSCN solubility effect may explain the slightly low faradaic efficiency of this process.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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Nanostructured Silicon-Based Heterojunction Solar Cells with Double Hole-Transporting Layers

Hybrid nanostructured silicon?organic solar cells have been pursued as a low-cost solution for silicon photovoltaic devices. However, it is difficult for the organic semiconductor, typically poly(3,4-ethylenedioxythiophene):polystyrene (PEDOT:PSS), to fully cover the nanostructured silicon surface due to the high surface tension of the polymer solution and the small size of the cavities in nanostructured silicon. As a result, the performance of the hybrid solar cells is limited by the defect-induced surface recombination and poor hole extraction. In this work, an inorganic hole-transporting layer, copper(I) thiocyanate (CuSCN), is introduced between silicon nanowire (SiNW) and PEDOT:PSS to improve the junction quality. The effect of CuSCN on as-fabricated SiNW and tetramethylammonium hydroxide (TMAH)-treated SiNW structures is examined, and it is shown that in both cases CuSCN can well cover the SiNW surface due to the easy penetration of its solution into the silicon nanostructure. As a result, the power conversion efficiency of the solar cells has been dramatically improved from 7.68% to 10.5% for as-fabricated SiNW-based-hybrid cells, and from 10.75% to 12.24% for TMAH-passivated SiNW-based-hybrid cells, suggesting that the double hole-transporting layer approach can effectively improve the junction quality in hybrid organic-nanostructured silicon-based devices.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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Application of 1111-67-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1111-67-7, molcular formula is CCuNS, introducing its new discovery.

Synthesis and Structural Studies of Coordination Position Isomers of Co(II) and Their Adducts with Some Lewis Bases

Coordination position isomers of the type (PPh3)2Co(NCS)2Cu2(SCN)2 and Co(NCS)2(PPh3)2Cu2(SCN)2 and their adducts of the type (xL)Co(NCS)2(PPh3)2Cu2(SCN)2 have been synthesized and studied on the basis of elemental analyses, molar conductance, magnetic susceptibility measurements, infrared and electronic spectral studies.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

Extracurricular laboratory:new discovery of Bis(acetylacetone)copper

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Synthesis of Cu2ZnSnS4 nanocrystals for use in low-cost photovoltaics

(Graph Presented) Cu2ZnSnS4 (CZTS) is a promising new material for thin-film solar cells. Nanocrystal dispersions, or solar paints, present an opportunity to significantly reduce the production cost of photovoltaic devices. This communication demonstrates the colloidal synthesis of CZTS nanocrystals and their use in fabricating prototype solar cells with a power conversion efficiency of 0.23% under AM 1.5 illumination.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”