In an article, author is Feng, Huangdi, once mentioned the application of 18742-02-4, Recommanded Product: 2-(2-Bromoethyl)-1,3-dioxolane, Name is 2-(2-Bromoethyl)-1,3-dioxolane, molecular formula is C5H9BrO2, molecular weight is 181.0278, MDL number is MFCD00003216, category is copper-catalyst. Now introduce a scientific discovery about this category.
Cu-Catalyzed Selective Synthesis of Propargylamines via A(3)-Coupling/Aza-Michael Addition Sequence: Amine Loading Controls the Selectivity
Propargylamines are valuable molecules in medicinal chemistry and organic synthesis. A(3) reaction is straightforward access to construct propargylamine and its derivatives. Here we report operationally simple catalytic domino A(3)-coupling/aza-Michael addition of a primary amine, formaldehyde solution, an alkyne, and an olefin using copper as a catalyst to produce a series of functionalized propargylamines in moderate to excellent yields. This protocol involves a competition between aza-Michael addition and Mannich reaction. By changing the amount loading of amines to control the process of Mannich reaction is the key procedure of increasing the selectivity.
If you are interested in 18742-02-4, you can contact me at any time and look forward to more communication. Recommanded Product: 2-(2-Bromoethyl)-1,3-dioxolane.
Reference:
Copper catalysis in organic synthesis – NCBI,
,Special Issue “Fundamentals and Applications of Copper-Based Catalysts”