In an article, author is Mohjer, Fatemeh, once mentioned the application of 16606-55-6, Product Details of 16606-55-6, Name is (R)-4-Methyl-1,3-dioxolan-2-one, molecular formula is C4H6O3, molecular weight is 102.09, MDL number is MFCD00798265, category is copper-catalyst. Now introduce a scientific discovery about this category.
Pd-free, Sonogashira cross-coupling reaction. An update
The Sonogashira reaction is a cross-coupling reaction used in organic synthesis to form carbon-carbon bonds. In its classical form, it uses a Pd catalyst as well as copper co-catalyst and amines as the solvents or co-solvents to form a carbon-carbon bond between a terminal alkyne and an aryl or vinyl halide. Due to the relatively high price of Pd and its toxicity, the Pd-free catalyzed Sonogashira cross-coupling reaction has attracted much attention from synthetic organic chemists, both in academia and industry. Several successful attempts have been made, which were introduced in a review article published in 2016. Due to a plethora of relevant papers that appeared in the chemical literature, in this review, we try to underline the recent advances achieved in the Pd-free Sonogashira reaction from 2016 to date. (C) 2021 Published by Elsevier B.V.
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Reference:
Copper catalysis in organic synthesis – NCBI,
,Special Issue “Fundamentals and Applications of Copper-Based Catalysts”