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Copper-catalyzed oxidative C-O coupling by direct C-H bond activation of formamides: Synthesis of enol carbamates and 2-carbonyl-substituted phenol carbamates
Formamide C-H bond activation has been achieved under oxidative conditions, using a copper catalyst and tert-butyl hydroperoxide (TBHP) as the external oxidant (see scheme). This oxidative coupling of a range of dialkyl formamides provides an easy, phosgene-free route for the selective synthesis of Z-enol carbamates and 2-carbonyl-substituted phenol carbamates in high yields. Copyright
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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”