In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1111-67-7, name is Cuprous thiocyanate, introducing its new discovery. Quality Control of Cuprous thiocyanate
Cu(I)-catalyzed, alpha-selective, allylic alkylation reactions between phosphorothioate esters and organomagnesium reagents
Regiocontrol of allylic alkylation reactions involving hard nucleophiles remains a significant challenge and continues to be an active area of research. The lack of general methods in which alpha-alkylation is favored underscores the need for the development of new processes for achieving this type of selectivity. We report that Cu(I) catalyzes the allylic substitution of phosphorothioate esters with excellent alpha-regioselectivity, regardless of the nature of the Grignard reagent that is used. To the best of our knowledge, the Cu-catalyzed allylic alkylation of phosphorothioate esters has never been described. We have also developed a simple protocol for inducing high alpha selectivity starting from secondary allylic halides. This is accomplished by using sodium phosphorothioates as an additive.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of Cuprous thiocyanate, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1111-67-7, in my other articles.
Reference：
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”