Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. Reference of 13395-16-9. Introducing a new discovery about 13395-16-9, Name is Bis(acetylacetone)copper
A facile, one-pot synthesis of 1H-indazoles featuring a Cu-catalyzed C?H ortho-hydroxylation and N?N bond-formation sequence with the use of pure oxygen as the terminal oxidant was developed. The reaction of readily available 2-arylaminobenzonitriles with various organometallic reagents led to ortho-arylamino N?H ketimine species. Subsequent Cu-catalyzed hydroxylation at the ortho position of the aromatic ring followed by N?N bond formation in DMSO under a pure-oxygen atmosphere afforded a wide variety of 1-(ortho-hydroxyaryl)-1H-indazoles in good to excellent yields. This efficient method does not require the utilization of noble-metal catalysts, elaborate directing groups, or privileged ligands.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! Read on for other articles about Reference of 146137-92-0!, Reference of 13395-16-9
Reference：
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”