Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 20859-23-8, is researched, SMILESS is O=C(O)[C@@H](Br)CC(O)=O, Molecular C4H5BrO4Journal, Tetrahedron called Copper-catalyzed cross-coupling of amino acid-derived amides with (Z)-vinyl iodides: Unexpected solvent effect and preparation of plocabulin, Author is Wang, Leiming; Lei, Xinsheng; Wang, Quanrui; Li, Yingxia, the main research direction is peptide plocabulin synthesis microtubule destabilizer agent; amino acid amide copper catalyzed cross coupling vinyl iodide.Electric Literature of C4H5BrO4.
A copper-catalyzed cross-coupling reaction of amino acid-derived amides and (Z)-vinyl iodide was studied to improve a key step in the synthesis of plocabulin, a novel microtubule destabilizer agent of marine origin. The study revealed a profound solvent effect with 1,2-dimethoxyethane (DME), which gave consistently high yields across a large variety of the amide and (Z)-vinyl iodide substrates. The protocol was successfully utilized in the preparation of plocabulin and provided a significantly improved yield.
If you want to learn more about this compound((S)-2-Bromosuccinic acid)Electric Literature of C4H5BrO4, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(20859-23-8).
Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”