The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-Hydroxyquinoline-2-carboxylic Acid(SMILESS: O=C(C1=NC2=CC=CC=C2C(O)=C1)O,cas:492-27-3) is researched.Synthetic Route of C9H8N2. The article 《Kynurenine pathway metabolites in cerebrospinal fluid and blood as potential biomarkers in Huntingtons disease》 in relation to this compound, is published in Journal of Neurochemistry. Let’s take a look at the latest research on this compound (cas:492-27-3).
Converging lines of evidence from several models, and post-mortem human brain tissue studies, support the involvement of the kynurenine pathway (KP) in Huntingtons disease (HD) pathogenesis. Quantifying KP metabolites in HD biofluids is desirable, both to study pathobiol. and as a potential source of biomarkers to quantify pathway dysfunction and evaluate the biochem. impact of therapeutic interventions targeting its components. In a prospective single-site controlled cohort study with standardised collection of cerebrospinal fluid (CSF), blood, phenotypic and imaging data, we used high-performance liquid-chromatog. to measure the levels of KP metabolites-tryptophan, kynurenine, kynurenic acid, 3-hydroxykynurenine, anthranilic acid and quinolinic acid-in CSF and plasma of 80 participants (20 healthy controls, 20 premanifest HD and 40 manifest HD). We investigated short-term stability, intergroup differences, associations with clin. and imaging measures and derived sample-size calculation for future studies. Overall, KP metabolites in CSF and plasma were stable over 6 wk, displayed no significant group differences and were not associated with clin. or imaging measures. We conclude that the studied metabolites are readily and reliably quantifiable in both biofluids in controls and HD gene expansion carriers. However, we found little evidence to support a substantial derangement of the KP in HD, at least to the extent that it is reflected by the levels of the metabolites in patient-derived biofluids.
As far as I know, this compound(492-27-3)Application of 492-27-3 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”