Synthetic Route of C20H28ClN3O6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, is researched, Molecular C20H28ClN3O6, CAS is 89396-94-1, about Estimation of Imidapril hydrochloride by UV – visible spectroscopic method in different solvents. Author is Prapulla, P.; Babu, B.; Maheshwari, T.; Paramesh, K.; Swathi, G.; Madhavi, K.; Hemamalini, K..
The objective of the project work was to developed and validated simple, accurate, rapid, precise, reproducible and cost effective spectrophotometric method for the quant. estimation of Imidapril HCl in different solvents like 0.1N HCl, Distilled water and 0.1N NaOH in bulk based on measurement of absorption at maximum wavelength and validated as per ICH guidelines. Imidapril hydrochloride is a angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension. Imidapril HCl showed absorption maximum (λmax) in different manner in different solvents like 0.1N Hydrochloric acid, Distilled Water and 0.1N Sodium Hydroxide Solution at 217 nm, 293 nm, and 236 nm resp. The drug exhibited maximum wavelength (nm) in distilled water, 293 nm when compared with other solvents due to the effect of solvent and chromophoric group. Thus the conclusion was made that the proposed UV Spectrophotometric method were found to be simple, rapid, accurate, precise, linear and more economical method has been developed for the quant. estimation of imidapril HCl in bulk. Hence, this method can be successfully and suitably acquired for routine quality control anal. of imidapril HC in bulk form.
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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”