Synthetic Route of Br2CuIn 2022 ,《Complement Activation Dramatically Accelerates Blood Plasma Fouling On Antifouling Poly(2-hydroxyethyl methacrylate) Brush Surfaces》 appeared in Macromolecular Bioscience. The author of the article were Riedel, Tomas; de los Santos Pereira, Andres; Taborska, Johanka; Riedelova, Zuzana; Pop-Georgievski, Ognen; Majek, Pavel; Pecankova, Klara; Rodriguez-Emmenegger, Cesar. The article conveys some information:
Non-specific protein adsorption (fouling) triggers a number of deleterious events in the application of biomaterials. Antifouling polymer brushes successfully suppress fouling, however for some coatings an extremely high variability of fouling for different donors remains unexplained. The authors report that in the case of poly(2-hydroxyethyl methacrylate) (poly(HEMA)) this variability is due to the complement system activation that causes massive acceleration in the fouling kinetics of blood plasma. Using plasma from various donors, the fouling kinetics on poly(HEMA) is analyzed and correlated with proteins identified in the deposits on the surface and with the biochem. compositions of the plasma. The presence of complement components in fouling deposits and concentrations of C3a in different plasmas indicate that the alternative complement pathway plays a significant role in the fouling on poly(HEMA) through the “”tick-over”” mechanism of spontaneous C3 activation. The generated C3b binds to the poly(HEMA) surface and amplifies complement activation locally. Heat-inactivated plasma prevents accelerated fouling kinetics, confirming the central role of complement activation. The results highlight the need to take into account the variability between individuals when assessing interactions between biomaterials and blood plasma, as well as the importance of the mechanistic insight that can be gained from protein identification.Cupric bromide(cas: 7789-45-9Synthetic Route of Br2Cu) was used in this study.
Cupric bromide(cas: 7789-45-9) can be used as reducing agent, when complexed by three molecules of pyridine initiators for the controlled polymerization of styrene, methyl acrylate and methyl methacrylate.Synthetic Route of Br2Cu
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”