Zhang, Xuexia’s team published research in Organic Letters in 20 | CAS: 14284-06-1

Organic Letters published new progress about 14284-06-1. 14284-06-1 belongs to copper-catalyst, auxiliary class Copper, name is Copper(II) ethylacetoacetate, and the molecular formula is C19H14Cl2, Category: copper-catalyst.

Zhang, Xuexia published the artcileCopper-Catalyzed Oxidative Coupling of AIBN and Ketone-Derived Enoxysilanes to γ-Ketonitriles, Category: copper-catalyst, the publication is Organic Letters (2018), 20(16), 4998-5001, database is CAplus and MEDLINE.

In the presence of Cu(MeCOCHCO2Et)2, acetophenone and benzalacetone trimethylsilyl enol ethers RC(OTMS):CH2 [R = Ph, 4-MeC6H4, 3-MeC6H4, 2-MeC6H4, 4-MeOC6H4, 4-FC6H4, 4-ClC6H4, 3-ClC6H4, 2-ClC6H4, 4-BrC6H4, 4-IC6H4, 4-F3CC6H4, 2-naphthyl, 2-furyl, 2-thienyl, 2-pyridinyl, 3-pyridinyl, (E)-PhCH:CH] underwent oxidative coupling with azobisalkanenitriles such as azobisisobutyronitrile (AIBN) mediated by Ag2CO3 in THF to yield γ-aryl-γ-ketonitriles such as RCOCH2CMe2CN [R = Ph, 4-MeC6H4, 3-MeC6H4, 2-MeC6H4, 4-MeOC6H4, 4-FC6H4, 4-ClC6H4, 3-ClC6H4, 2-ClC6H4, 4-BrC6H4, 4-IC6H4, 4-F3CC6H4, 2-naphthyl, 2-furyl, 2-thienyl, 2-pyridinyl, 3-pyridinyl, (E)-PhCH:CH] in 22-91% yields. Attempted oxidative coupling in the presence of bis(oxazolinyl)pyridines yielded products with no enantioselectivity.

Organic Letters published new progress about 14284-06-1. 14284-06-1 belongs to copper-catalyst, auxiliary class Copper, name is Copper(II) ethylacetoacetate, and the molecular formula is C19H14Cl2, Category: copper-catalyst.

Referemce:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660968/,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”