Photoredox/copper cocatalyzed domino cyclization of oxime esters with TMSCN: access to antifungal active tetrasubstituted pyrazines was written by Cao, Shujun;Yuan, Weidong;Li, Yun;Teng, Xinjie;Si, Huaxing;Chen, Rongshun;Zhu, Yingguang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Electric Literature of C2CuF6O6S2 This article mentions the following:
A photoredox/copper cocatalyzed domino cyclization of oxime esters R1C(CH2R2)=NOC(O)(4-CF3C6H4) (R1 = Ph, 2-thienyl, Me, etc.; R2 = Ph, 1H-pyrazol-1-ylmethyl, methoxymethyl, etc.) with TMSCN has been developed. A range of structurally novel tetrasubstituted pyrazines I have been obtained. This method features high bond-forming efficiency, high step economy, broad substrate scope, and gram-scale synthesis. Moreover, preliminary bioactivity evaluation of pyrazine products I shows their promising antifungal activities. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Electric Literature of C2CuF6O6S2).
Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Copper has continued to be one of the most utilized and important transition metal catalysts in synthetic organic chemistry. Copper nanoparticles can catalyze the Ullmann coupling reaction in a wide range of applications.Electric Literature of C2CuF6O6S2
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”