A Counterion/Ligand-Tuned Chemo- and Enantioselective Copper-Catalyzed Intermolecular Radical 1,2-Carboamination of Alkenes was written by Cheng, Xian-Yan;Zhang, Yu-Feng;Wang, Jia-Huan;Gu, Qiang-Shuai;Li, Zhong-Liang;Liu, Xin-Yuan. And the article was included in Journal of the American Chemical Society in 2022.Formula: C10H2CuF12O4 This article mentions the following:
The copper-catalyzed enantioselective intermol. radical 1,2-carboamination of alkenes with readily accessible alkyl halides was an appealing strategy for producing chiral amine scaffolds. The challenge arised from the easily occurring atom transfer radical addition between alkyl halides and alkenes and the issue of enantiocontrol. A radical alkene 1,2-carboamination with sulfoximines in a highly chemo- and enantioselective manner was described. The key to the success of this process is the conceptual design of a counterion/highly sterically demanded ligand coeffect to promote the ligand exchange of copper(I) with sulfoximines and forge chiral C-N bonds between alkyl radicals and the chiral copper(II) complex. The reaction covered alkenes bearing distinct electronic properties, such as aryl-, heteroaryl-, carbonyl- and aminocarbonyl-substituted ones and various radical precursors, including alkyl chlorides, bromides, iodides and the CF3 source. In the experiment, the researchers used many compounds, for example, copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4Formula: C10H2CuF12O4).
copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4) belongs to copper catalysts. Copper catalyst has received great attention owing to the low toxicity and low cost. Copper nanoparticles can also catalyze the coupling reaction of nitrogen-containing nucleophiles, phenols, thiols, xanthogenates, selenium ruthenium nucleophiles and the like.Formula: C10H2CuF12O4
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”