Total synthesis of himastatin was written by D’Angelo, Kyan A.;Schissel, Carly K.;Pentelute, Bradley L.;Movassaghi, Mohammad. And the article was included in Science (Washington, DC, United States) in 2022.Application of 34946-82-2 This article mentions the following:
The natural product himastatin has an unusual homodimeric structure that presents a substantial synthetic challenge. We report the concise total synthesis of himastatin from readily accessible precursors, incorporating a final-stage dimerization strategy that was inspired by a detailed consideration of the compound’s biogenesis. Combining this approach with a modular synthesis enabled expedient access to more than a dozen designed derivatives of himastatin, including synthetic probes that provide insight into its antibiotic activity. The synthesis and study of antibiotic natural products with unique structures and mechanisms of action represents a proven strategy to combat the public health crisis posed by antibiotic-resistant bacteria. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Application of 34946-82-2).
Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The evolution of transition metal catalysts has attained a stage of civilization that authorizes for an extensive scope of chemical bonds formation partners to be combined efficiently. It is clear from the impact copper catalysis has had on organic synthesis that copper should be considered a first line catalyst for many organic reactions.Application of 34946-82-2
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”