Copper-Catalyzed, N-Directed Distal C(sp3)-H Functionalization toward Azepanes was written by Yang, Jia-Wen;Tan, Guang-Qiang;Liang, Kai-Cheng;Xu, Ke-Dong;Su, Ma;Liu, Feng. And the article was included in Organic Letters in 2022.Related Products of 34946-82-2 This article mentions the following:
A copper-catalyzed formal [5 + 2] aza-annulation of N-fluorosulfonamides and 1,3-dienes/1,3-enynes for synthesis of structurally diverse alkene/alkyne-containing azepanes such as I [R1 = H, Me, Et; R2 = Me, Et; R1R2 = (CH2)4, (CH2)5; R3 = H, Me; R4 = Ph, n-hexyl, 4-MeC6H4, etc.; Ar = Ph, 4-MeOC6H4, 2-thienyl, etc.] and II [Ar1 = Ph, 4-ClC6H4, 4-MeC6H4, etc.; Ar = Ph, 4-phenylphenyl, 4-MeC6H4, 4-BrC6H4, 4-MeOC6H4] was reported. The reaction features selective functionalization of distal unactivated C(sp3)-H bonds and a broad substrate scope, thus allowing the late-stage modification of pharmaceuticals and natural products. A radical mechanism involving 1,5-hydrogen atom transfer of N-radicals, facile coupling of alkyl radicals with 1,3-dienes/1,3-enynes, and the construction of azepane motifs via C-N bond formation was proposed. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Related Products of 34946-82-2).
Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Copper catalyst has received great attention owing to the low toxicity and low cost. These ligands enable the reaction promoted in mild condition. The reaction scope has also been greatly expanded, rendering this copper-based cross-coupling attractive for both academia and industry. Related Products of 34946-82-2
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”