Remote Functionalization of 8-Substituted Quinolines with para-Quinone Methides: Access to Unsymmetrical Tri(hetero)arylmethanes was written by Burra, Amarender G.;Uredi, Dilipkumar;Motati, Damoder R.;Fronczek, Frank R.;Watkins, E. Blake. And the article was included in European Journal of Organic Chemistry in 2022.Electric Literature of C2CuF6O6S2 This article mentions the following:
A C(5)-H remote functionalization of para-quinone methides I (R = Me, tert-Bu, phenyl; Ar = C(O)2Et, Ph, 2-pyrenyl, etc.) with 8-aminoquinoline derivatives, II (R1 = acetyl, benzyl, (4-methylbenzene)sulfonyl, etc.; R2 = H, benzyl; R3 = H, Br; R4 = H, OMe) affording direct access to unsym. tri(hetero)arylmethanes III in 69-96% yield is described. This method provides diverse tri(hetero)arylmethanes III with a broad scope and in a regioselective manner. The transformation works well with electron-rich and electron-deficient substrates. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Electric Literature of C2CuF6O6S2).
Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to the earth-abundant, inexpensive and low toxicity. Copper nanoparticles can also catalyze the coupling reaction of nitrogen-containing nucleophiles, phenols, thiols, xanthogenates, selenium ruthenium nucleophiles and the like.Electric Literature of C2CuF6O6S2
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”