14347-78-5, Name is (R)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol, molecular formula is C6H12O3, Recommanded Product: 14347-78-5, belongs to copper-catalyst compound, is a common compound. In a patnet, author is Keivanloo, Ali, once mentioned the new application about 14347-78-5.
Synthesis of hydantoin alkynes through palladium-catalyzed reaction, antibacterial evaluation, and molecular docking studies
Novel 3-(3-(aryl)prop-2-yn-1-yl)-5,5-diphenylimidazolidine-2,4-diones were synthesized through the reaction of 5,5-diphenyl-3-(prop-2-yn-1-yl)imidazolidine-2,4-dione and aryl iodides in the presence of a palladium-copper catalytic in CH3CN at room temperature. All prepared compounds were examined against the two bacterial strains, Micrococcus luteus and Pseudomonas aeruginosa and subjected by molecular docking studies. The in silico study carried out to predict the conformation of the examined compounds recommended that these compounds could bind noticeably to key the residues at the active site of dihydropteroate synthase. The interactive, biochemical, and in silico studies were in concordance with each other.
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Reference:
Copper catalysis in organic synthesis – NCBI,
,Special Issue “Fundamentals and Applications of Copper-Based Catalysts”