Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Drug Development and Industrial Pharmacy called Effect of pharmaceutical excipients on the stability of angiotensin-converting enzyme inhibitors in their solid dosage formulations, Author is Stanisz, Beata; Regulska, Katarzyna; Kania, Jagoda; Garbacki, Piotr, which mentions a compound: 89396-94-1, SMILESS is O=C([C@H](CN1C)N(C([C@@H](N[C@@H](CCC2=CC=CC=C2)C(OCC)=O)C)=O)C1=O)O.[H]Cl, Molecular C20H28ClN3O6, Application of 89396-94-1.
The compatibility studies of moexipril hydrochloride (MOXL), imidapril hydrochloride (IMD), enalapril maleate, (ENA) and lisinopril (LIS) in solid state with magnesium stearate and glyceryl behenate were performed. The aim of this study was to detect any possible drug-excipient interactions to optimize technol. process conditions by the selection of the most adequate lubricant. Reversed-phase high-performance liquid chromatog. was employed for studying drug-excipient binary mixtures in 1:1 ratio and pure drugs under forced aging test conditions: temperature 318K (45°C) and relative humidity range of 50.9%-75.4%. The method had been revalidated prior to use. The degradation rate constants for the binary mixtures and pure substances were calculated The exptl. results evidenced that moexipril and enalapril degradation accorded with autocatalytic-second-order kinetics, imidapril degradation followed first-order reaction mechanism, and LIS followed reversible first-order reaction mechanism. A degradation pathway for each substance was proposed to account for the observed decomposition products. It was determined that moexipril stability decreased 3-fold in the presence of magnesium stearate indicating an incompatibility – (4.15 ± 0.12) 10-3 compared to (1.43 ± 0.32) 10-6 for moexipril in pure. No interaction between magnesium stearate and the remaining studied compounds was observed The stability studies of MOXL-glyceryl behenate binary mixture revealed no interaction. Magnesium stearate and increased relative humidity induce MOXL instability, while glyceryl behenate is an optimal lubricant, and therefore, it is recommended for moexipril-containing solid formulations. However, for the formulations containing moexipril and magnesium stearate, it is suggested to minimize the humidity level during storage.
In addition to the literature in the link below, there is a lot of literature about this compound((S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride)Application of 89396-94-1, illustrating the importance and wide applicability of this compound(89396-94-1).
Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”