Tf2O- and Cu(OTf)2-Assisted Acylamination Reaction of Unactivated Alcohols with Nitriles: A One-Pot P(IV) Activation, Stereoretention in Cycloalkanols and Deprotection Approach was written by Bhat, Mohammad Yaqoob;Ahmed, Sajjad;Ahmed, Qazi Naveed. And the article was included in Journal of Organic Chemistry in 2022.Category: copper-catalyst This article mentions the following:
Described herein is a simple, novel, one-pot acylamination reaction of unactivated alcs. This reaction employs the combination of PCl3 and triflic anhydride (Tf2O) or copper triflate Cu(OTf)2, which serves as a source of P(IV)-activated complex for nitriles to react under the Ritter-type mechanism. The synthetic utility of Tf2O-promoted reactions was demonstrated by its effectiveness to generate different acylaminated products. By employing Cu(OTf)2, this method represented a rare example of α-selective acylamination reaction. With chiral cycloalkanols, using the Cu(OTf)2-promoted procedure, acylaminated products were formed with complete retention of configuration. The synthetic utility of the copper-assisted reaction in acetonitrile was readily demonstrated as a mild deprotection strategy. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Category: copper-catalyst).
Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to the earth-abundant, inexpensive and low toxicity. It is clear from the impact copper catalysis has had on organic synthesis that copper should be considered a first line catalyst for many organic reactions.Category: copper-catalyst
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”