Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1207176-24-6, is researched, Molecular C11H19BrFNO2, about Synthesis of aminomethylated 4-fluoropiperidines and 3-fluoropyrrolidines, the main research direction is aminomethylated fluoropiperidine fluoropyrrolidine preparation; exomethylenepyrrolidine bromosuccinamide hydrogenfluoride bromofluorination; sodium azide nucleophilic displacement reduction.Electric Literature of C11H19BrFNO2.
A short and efficient synthesis of 4-aminomethyl-4-fluoropiperidines, e.g., I and 3-aminomethyl-3-fluoropyrrolidines, e.g., II is described. These fluorinated azaheterocycles are of specific interest as bifunctional building blocks for fluorinated pharmaceutical compounds The key step of the synthetic pathway involves the regioselective bromofluorination of N-Boc-4-methylenepiperidine and 3-methylenepyrrolidine using Et3N.3HF and NBS.
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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”