Category: 148857-42-5

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Excited states of the phthalimide chromophore and their exciton couplings: a tool for stereochemical assignments, published in 1998-11-25, which mentions a compound: 148857-42-5, mainly applied to phthalimide chromophore exciton coupling stereochem assignment, Safety of (S)-2-(3-Chloro-2-hydroxypropyl)isoindoline-1,3-dione.

Electronically excited states of the phthalimide chromophore were studied by linear dichroism (LD) of samples partially oriented in poly(vinyl alc.) films, magnetic CD (MCD), and CD spectroscopy. On the basis of the LD measurements, the low-energy tail (340-320 nm) of the 1st absorption band is assigned to an out-of-plane polarized n→π* transition (I). At higher energy, the electronic spectrum is resolved into contributions from 5 π→π* transitions: II (300 nm, long-axis polarized), III (275 nm, short-axis polarized), IV (235 nm, short-axis polarized), V (220 nm, long-axis polarized), and VI (∼210 nm, short-axis polarized). The results from semiempirical (INDO/S-CI) and ab initio (CIS/6-31+G(d)) MO calculations compare well with the proposed assignments of the excited states. Degenerate exciton interaction between elec.-dipole-allowed transitions of 2 phthalimide chromophores is observed in the electronic absorption spectra of the achiral bis-phthalimides I (n = 0-2) and in the CD spectrum of the chiral bis-phthalimide II (X = phthalimido). For the latter compound, the solid-state geometry was determined by x-ray diffraction. Good agreement between exptl. and computed CD spectra confirms that the coupled-oscillator exciton model provides the basis for a reliable nonempirical method for the assignment of absolute configuration for this class of compounds Nondegenerate exciton coupling between phthalimide and benzoate or Ph chromophores is borne out in the CD spectra of homochiral mols. II (X = OBz, Ph) with a rigid cyclohexane skeleton. Finally, the exciton-coupling method is used to make stereochem. assignments for the acyclic, conformationally flexible derivatives RCHMeCH2X (R = phthalimido throughout this abstract; X = R, OBz), RCH2CHMeOBz and RCH2CH(OBz)CH2Cl.

After consulting a lot of data, we found that this compound(148857-42-5)Safety of (S)-2-(3-Chloro-2-hydroxypropyl)isoindoline-1,3-dione can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Formula: C11H10ClNO3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-2-(3-Chloro-2-hydroxypropyl)isoindoline-1,3-dione, is researched, Molecular C11H10ClNO3, CAS is 148857-42-5, about A new and concise synthetic route to enantiopure linezolid from (S)-epichlorohydrin. Author is Rajesh, T.; Madhusudhan, G.; Mukkanti, K.; Rao, S. P. Narayana; Babu, K. Kishore.

The synthesis of the target compound was achieved [Linezolid, N-[[(5S)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide] by two pathways. The synthetic route in both ways involves preparation of 2-[(R)-3-(3-fluoro-4-morpholinophenyl)amino-2-hydroxypropyl]-1,3-isoindolinedione (I) as a key intermediate starting from (S)-epichlorohydrin and phthalimide. One of these methods involves a direct N-alkylation of 3-fluoro-4-morpholinoaniline with 2-[(S)-3-chloro-2-hydroxypropyl]-1,3-isoindolinedione. Alternatively, I was prepared by a one-pot three-step sequence via 2-[[(S)-2-oxiranyl]methyl]-1,3-isoindolinedione.

Although many compounds look similar to this compound(148857-42-5)Formula: C11H10ClNO3, numerous studies have shown that this compound(SMILES:O=C1N(C[C@H](O)CCl)C(C2=C1C=CC=C2)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Recommanded Product: (S)-2-(3-Chloro-2-hydroxypropyl)isoindoline-1,3-dione. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-2-(3-Chloro-2-hydroxypropyl)isoindoline-1,3-dione, is researched, Molecular C11H10ClNO3, CAS is 148857-42-5, about A phosphonium ylide as a visible light organophotoredox catalyst. Author is Toda, Yasunori; Tanaka, Katsumi; Matsuda, Riki; Sakamoto, Tomoyuki; Katsumi, Shiho; Shimizu, Masahiro; Ito, Fuyuki; Suga, Hiroyuki.

A phosphonium ylide-based visible light organophotoredox catalyst was designed and successfully applied to halohydrin synthesis using trichloroacetonitrile and epoxides. An oxidative quenching cycle by the ylide catalyst was established, which was confirmed by exptl. mechanistic studies.

I hope my short article helps more people learn about this compound((S)-2-(3-Chloro-2-hydroxypropyl)isoindoline-1,3-dione)Recommanded Product: (S)-2-(3-Chloro-2-hydroxypropyl)isoindoline-1,3-dione. Apart from the compound(148857-42-5), you can read my other articles to know other related compounds.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Category: copper-catalyst. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-2-(3-Chloro-2-hydroxypropyl)isoindoline-1,3-dione, is researched, Molecular C11H10ClNO3, CAS is 148857-42-5, about Taking advantage of lithium monohalocarbenoid intrinsic α-elimination in 2-MeTHF: controlled epoxide ring-opening en route to halohydrins. Author is Ielo, Laura; Miele, Margherita; Pillari, Veronica; Senatore, Raffaele; Mirabile, Salvatore; Gitto, Rosaria; Holzer, Wolfgang; Alcantara, Andres R.; Pace, Vittorio.

A straightforward preparation of different β-halohydrins RCR1(OH)CH2X [R = Ph, 4-ClC6H4, 1,3-dioxoisoindolin-2-yl, etc.; R1 = H, Me, CF3, Ph; X = Cl, Br, I] through boosted Kirmse’s elimination of the corresponding lithium monohalocarbenoids starting from epoxide. Crucial for the development of the method was the use of the eco-friendly solvent 2-MeTHF, which forces the degradation of the incipient monohalolithium, due to the very limited stabilizing effect of this solvent on the chem. integrity of the carbenoid. The uniformly high-yield, the full preservation of the embodied stereochem. information and the high regiocontrol – deduced by selectively preparing variously decorated motifs further document the potential of this operationally simpleand intuitive methodol.

I hope my short article helps more people learn about this compound((S)-2-(3-Chloro-2-hydroxypropyl)isoindoline-1,3-dione)Category: copper-catalyst. Apart from the compound(148857-42-5), you can read my other articles to know other related compounds.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Application of 148857-42-5. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-2-(3-Chloro-2-hydroxypropyl)isoindoline-1,3-dione, is researched, Molecular C11H10ClNO3, CAS is 148857-42-5, about An expeditious construction of 3-aryl-5-(substituted methyl)-2-oxazolidinones: a short and efficient synthesis of linezolid. Author is Tammana, Rajesh; Vemula, Kiran Kumar; Guruvindapalli, Ramadasu; Yanamandra, Ramesh; Gutta, Madhusudhan.

A short, concise, and efficient synthesis of linezolid was accomplished through a convergent scheme utilizing either (S)-1-azido-3-chloroprop-2-yl chloroformate or (S)-1-phthalimido-3-chloroprop-2-yl chloroformate as key starting material. The synthesis demonstrates the utility of the chloroformates to facilitate the expeditious construction of 3-aryl-5-(substituted methyl)-2-oxazolidinones and offers the possibility to access related 2-oxazolidinone members easily as well as prepare addnl. analogs of linezolid.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”