Category: 89396-94-1

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Kinetics of degradation of imidapril hydrochloride in finished dosage formulations, published in 2013-08-31, which mentions a compound: 89396-94-1, mainly applied to imidapril hydrochloride tablet stability degradability HPLC, Category: copper-catalyst.

This study investigates the impact of relative air humidity and temperature on the stability of imidapril hydrochloride (IMD) tablets. For this purpose the forced degradation test was used and the following environmental conditions were employed: RH = 76.4% and the temperature range of 313 – 333 K. For the determination of IMD content in the analyzed samples a reversed-phase high performance liquid chromatog. (RP-HPLC) technique was used. Three series of tablets were prepared: whole-blistered tablets, whole-bare tablets and halved-bare tablets, in order to analyze the influence of different in-home storage habits on IMD tablets’ quality. In the course of the study, the degradation of IMD was observed in each series of tablets. The kinetic mechanisms and the thermodn. parameters of these reactions were established. It was evidenced that halved IMD tablets stored without immediate packaging retain their quality only for 12 days while tablets stored according to label recommendations are stable for 513 days.

《Kinetics of degradation of imidapril hydrochloride in finished dosage formulations》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride)Category: copper-catalyst.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Reference of (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, is researched, Molecular C20H28ClN3O6, CAS is 89396-94-1, about Bioequivalence study of Imidapril hydrochloride tablets 10mg in healthy male volunteers: comparison of Imidapril hydrochloride tablets 10mg “”TCK”” and Imidapril hydrochloride tablets 10mg “”TYK”” with Tanatril tablets 10. Author is Tanaka, Kazuhiko.

To investigate the bioequivalence of Imidapril hydrochloride tablets 10 mg [TCK] and Imidapril hydrochloride tablets 10 mg [TYK] (test product) with Tanatril tablets 10 (reference product), these were administered to healthy male adult subjects in a two-way, two-period crossover study and their bioavailability were compared by the parameters of AUCt and Cmax determined from plasma concentrations of unchanged imidapril. Since the 90% confidence intervals of the differences between the means of the logarithmic AUCt and Cmax of the test and reference products were within the acceptable range specified in the “”Guideline for bioequivalence studies of generic products””, it was concluded that the two test products were equivalent to the reference one biol.

《Bioequivalence study of Imidapril hydrochloride tablets 10mg in healthy male volunteers: comparison of Imidapril hydrochloride tablets 10mg “”TCK”” and Imidapril hydrochloride tablets 10mg “”TYK”” with Tanatril tablets 10》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride)Reference of (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Synthetic Route of C20H28ClN3O6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, is researched, Molecular C20H28ClN3O6, CAS is 89396-94-1, about Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily a polypeptide-4-influencing drugs during hypokalemia due to licorice. Author is Miyamoto, Kanyu; Kawai, Hirohisa; Aoyama, Ryuhei; Watanabe, Hitoshi; Suzuki, Keisuke; Suga, Norihiro; Kitagawa, Wataru; Miura, Naoto; Nishikawa, Kazuhiro; Imai, Hirokazu.

We report an 82-yr-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia. He had hypokalemia (K 2.3 mmol/L) induced by licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy. After taking him off all drugs and administering spironolactone supplemented with potassium, his low serum potassium level was ameliorated. Therefore, although garenoxacin reportedly causes fewer adverse reactions for cardiac rhythms than third-generation quinolone antibiotics, one must be cautious of the interference of other drugs during hypokalemia in order to prevent TdP.

Different reactions of this compound((S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride)Synthetic Route of C20H28ClN3O6 require different conditions, so the reaction conditions are very important.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride(SMILESS: O=C([C@H](CN1C)N(C([C@@H](N[C@@H](CCC2=CC=CC=C2)C(OCC)=O)C)=O)C1=O)O.[H]Cl,cas:89396-94-1) is researched.Quality Control of 4-Hydroxyquinoline-2-carboxylic Acid. The article 《Serum substance P concentrations and silent aspiration in elderly patients with stroke》 in relation to this compound, is published in Neurology. Let’s take a look at the latest research on this compound (cas:89396-94-1).

Various doses of angiotensin-converting enzyme (ACE) inhibitors were administered to elderly patients with stroke to determine the effective concentration of serum substance P (SP) that correlates best with improvement of the silent aspiration in such patients. ACE inhibitors improved the silent aspiration in elderly patients with stroke via increasing the serum SP. Serum SP may be a useful marker for monitoring the control of silent aspiration in such patients and its optimal concentration was about 70 pg/mL. Results also suggest an important role of SP-containing nerves in the initiation of protective reflexes.

Different reactions of this compound((S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride)Synthetic Route of C20H28ClN3O6 require different conditions, so the reaction conditions are very important.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Synthetic Route of C20H28ClN3O6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, is researched, Molecular C20H28ClN3O6, CAS is 89396-94-1, about Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily a polypeptide-4-influencing drugs during hypokalemia due to licorice. Author is Miyamoto, Kanyu; Kawai, Hirohisa; Aoyama, Ryuhei; Watanabe, Hitoshi; Suzuki, Keisuke; Suga, Norihiro; Kitagawa, Wataru; Miura, Naoto; Nishikawa, Kazuhiro; Imai, Hirokazu.

We report an 82-yr-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia. He had hypokalemia (K 2.3 mmol/L) induced by licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy. After taking him off all drugs and administering spironolactone supplemented with potassium, his low serum potassium level was ameliorated. Therefore, although garenoxacin reportedly causes fewer adverse reactions for cardiac rhythms than third-generation quinolone antibiotics, one must be cautious of the interference of other drugs during hypokalemia in order to prevent TdP.

Different reactions of this compound((S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride)Synthetic Route of C20H28ClN3O6 require different conditions, so the reaction conditions are very important.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride(SMILESS: O=C([C@H](CN1C)N(C([C@@H](N[C@@H](CCC2=CC=CC=C2)C(OCC)=O)C)=O)C1=O)O.[H]Cl,cas:89396-94-1) is researched.Quality Control of 4-Hydroxyquinoline-2-carboxylic Acid. The article 《Serum substance P concentrations and silent aspiration in elderly patients with stroke》 in relation to this compound, is published in Neurology. Let’s take a look at the latest research on this compound (cas:89396-94-1).

Various doses of angiotensin-converting enzyme (ACE) inhibitors were administered to elderly patients with stroke to determine the effective concentration of serum substance P (SP) that correlates best with improvement of the silent aspiration in such patients. ACE inhibitors improved the silent aspiration in elderly patients with stroke via increasing the serum SP. Serum SP may be a useful marker for monitoring the control of silent aspiration in such patients and its optimal concentration was about 70 pg/mL. Results also suggest an important role of SP-containing nerves in the initiation of protective reflexes.

Different reactions of this compound((S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride)Synthetic Route of C20H28ClN3O6 require different conditions, so the reaction conditions are very important.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride( cas:89396-94-1 ) is researched.Safety of (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride.Satake, Kazuo; Yasuda, Kuninobu; Hashizume, Shigetoshi; Shinohara, Hiroshi; Nakamura, Noriko published the article 《Bioequivalence trial of imidapril hydrochloride tablets 2.5 mg “”TOWA””, imidapril hydrochloride tablets 5 mg “”TOWA”” and imidapril hydrochloride tablets 10 mg “”TOWA”” in health human volunteers》 about this compound( cas:89396-94-1 ) in Igaku to Yakugaku. Keywords: imidapril hydrochloride tablet bioequivalence generic drug. Let’s learn more about this compound (cas:89396-94-1).

Here, the authors examined the bioequivalence of imidapril hydrochloride tablets with different amounts of imidapril hydrochloride on health human volunteers. The results demonstrated the bioequivalence of imidapril hydrochloride tablets to Tanatril tablets (reference products).

The article 《Bioequivalence trial of imidapril hydrochloride tablets 2.5 mg “”TOWA””, imidapril hydrochloride tablets 5 mg “”TOWA”” and imidapril hydrochloride tablets 10 mg “”TOWA”” in health human volunteers》 also mentions many details about this compound(89396-94-1)Safety of (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, you can pay attention to it, because details determine success or failure

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 89396-94-1, is researched, Molecular C20H28ClN3O6, about An angiotensin converting enzyme inhibitor suppresses contrast media induced renal dysfunction in a murine model of subtotal nephrectomy, the main research direction is ACE inhibitor contrast media nephrectomy renal dysfunction.SDS of cas: 89396-94-1.

Backgrounds: Contrast media (CM)-induced nephropathy (CIN) affects morbidity and mortality in humans. Although CIN is mediated by several factors including the renin-angiotensin system (RAS), little is known about the pathophysiol. To clarify the mechanism, we developed a novel murine CIN model. Methods: We made 5/6 subtotal nephrectomy (NTX) and administered CM (iopamidol) i.v. into the mice 4 wk after NTX. Mice received an angiotensin converting enzyme inhibitor (ACEI, n = 6), an angiotensin II receptor blocker (ARB, n = 4), or ACEI plus a bradykinin B2 receptor antagonist (Hoe-140, n = 5) daily. Results: Serum creatinine levels were significantly elevated in the NTX group compared to the non-NTX group on day 28. A day after CM injection, creatinine levels were addnl. elevated in the non-treated group. While ACEI treatment significantly suppressed the creatinine levels, ARB treatment did not decrease the levels. Hoe-140 negated ACEI’s ability to suppress renal dysfunction. Conclusion: ACEI treatment may be useful for the prevention of CM-induced nephropathy.

The article 《An angiotensin converting enzyme inhibitor suppresses contrast media induced renal dysfunction in a murine model of subtotal nephrectomy》 also mentions many details about this compound(89396-94-1)SDS of cas: 89396-94-1, you can pay attention to it, because details determine success or failure

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 89396-94-1, is researched, Molecular C20H28ClN3O6, about Pharmacological studies on (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxoimidazolidine-4-carboxylic acid hydrochloride (TA-6366), a new ACE inhibitor: I. ACE inhibitory and anti-hypertensive activities, the main research direction is TA 6366 antihypertensive ACE inhibition; angiotensin converting enzyme inhibitor TA6366 antihypertensive.Recommanded Product: 89396-94-1.

TA-6366 and its active metabolite 6366A inhibited swine renal angiotensin converting enzyme (ACE) activity with IC50s of 9900 and 2.6 nM, resp. TA-6366 (0.05-0.5 mg/kg, oral) inhibited the angiotensin I (AT-I)-induced pressor response in rats. 6366A augmented bradykinin (BK)-induced contraction of guinea pig ileum more potently than captopril. However, when the augmentation on BK-induced hypotension in rats was used as an indicator, TA-6366 was less active than captopril. TA-6366 increased plasma renin activity and plasma AT-I concentration Oral administration of TA-6366 lowered the blood pressure in two-kidney one-clip renal hypertensive rats at 0.5 to 2 mg/kg and in spontaneously hypertensive rats (SHRs) at 2 to 10 mg/kg. The antihypertensive effect of TA-6366 was approx. 5 times more potent than that of captopril and almost as potent as that of enalapril. In SHRs, the antihypertensive action of TA-6366 was intensified in potency when administered repeatedly. The duration of action was longer than those of captopril and enalapril. However, TA-6366-had no substantial effect on the blood pressure in DOCA/saline hypertensive rats. These results indicate that TA-6366 is a potent and long lasting antihypertensive agent and that its antihypertensive action is attributable to the inhibition of ACE.

The article 《Pharmacological studies on (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxoimidazolidine-4-carboxylic acid hydrochloride (TA-6366), a new ACE inhibitor: I. ACE inhibitory and anti-hypertensive activities》 also mentions many details about this compound(89396-94-1)Recommanded Product: 89396-94-1, you can pay attention to it, because details determine success or failure

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 89396-94-1, is researched, Molecular C20H28ClN3O6, about Optimization of Storage and Manufacture Conditions for Imidapril Hydrochloride in Solid State as a Way to Reduce Costs of Antihypertensive Therapy, the main research direction is imidapril hydrochloride temperature relative humidity storage.COA of Formula: C20H28ClN3O6.

The effect of temperature and relative humidity (RH) on the stability of imidapril hydrochloride (IMD) in solid state was investigated. The main aim of this study was to determine the most appropriate conditions of storage and manufacture of IMD so that the efficiency of the technol. process could be improved and its costs could be minimized. A reversed-phase high-performance liquid chromatog. was validated and applied for the determination of IMD degradation samples under the following operating conditions: stationary phase, LiChrospher 100 RP-18 (size 5 μm) 250×4 mm I.D., and mobile phase, acetonitrile-methanol-phosphate buffer, pH 2.0, 0.035 mol L-1 (60:10:30 volume/volume/v). The effect of temperature on IMD degradation rate was analyzed under increased RH ∼76.4% (within temperature range of 70-90°C) and decreased RH ∼0% (within temperature range of 90-110°C). The influence of RH was investigated under 90°C within RH range of 25.0-76.4%. IMD degradation accords with autocatalytic reaction model, and RH has no influence on its mechanism yet it increases its rate. The reaction also accelerates under high temperatures and in the presence of IMD degradation product. Pure IMD is more stable than other structurally related angiotensin-converting enzyme inhibitors, such as enalapril maleate, but it still should be stored in tightly closed containers and protected from moisture and high temperatures

After consulting a lot of data, we found that this compound(89396-94-1)COA of Formula: C20H28ClN3O6 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”