Category: 89396-94-1

HPLC of Formula: 89396-94-1. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, is researched, Molecular C20H28ClN3O6, CAS is 89396-94-1, about Simultaneous estimation of imidapril hydrochloride and hydrochlorothiazide by RP-HPLC. Author is Veditha, K.; Sailaja, B..

A simple isocratic reverse phase high performance liquid chromatog. (RP-HPLC) method has been developed and subsequently validated for simultaneous estimation of anti-hypertensive drugs, Imidapril(IMP) and Hydrochlorothiazide (HTZ) in tablet formulation. Quantification was carried out by using an isocratic mode on HPLC of Phenomenex Luna (C18 250 × 4.6 mm, 5 μ) with flow rate of 1.0 mL/min and UV detection at 218nm. The separation was carried out using a mobile phase consisting of phosphate buffer: acetonitrile: methanol (58: 25: 17 volume/volume) and adjusted the pH to 2.5. The retention time for IMP and HTZ was found to be 6.243min and 2.370min resp. A linear response was observed over the concentration range of 5-30 mcg/mL each for the assay of IMP and HTZ. The results of anal. were validated and recovery was found to be <98%. Hence the proposed method was found to be accurate, precise, reproducible and specific and could be used for simultaneous anal. of these drugs in tablet formulation. After consulting a lot of data, we found that this compound(89396-94-1)HPLC of Formula: 89396-94-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Utsumi, Kouichi; Yasuda, Fumihiko; Watanabe, Yoko; Higo, Seiichiro; Hirama, Akio; Fujita, Emiko; Ueda, Kae; Mii, Akiko; Kaneko, Tomohiro; Mishina, Masahiro; Iino, Yasuhiko; Katayama, Yasuo researched the compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride( cas:89396-94-1 ).Recommanded Product: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride.They published the article 《Effects of olmesartan and imidapril on the plasma adiponectin, P-selectin, and MDA-LDL levels of diabetic nephropathy patients》 about this compound( cas:89396-94-1 ) in Clinica Chimica Acta. Keywords: olmesartan medoxomil imidapril hydrochloride adiponectin Pselectin diabetic nephropathy antioxidant. We’ll tell you more about this compound (cas:89396-94-1).

The effects of olmesartan and imidapril on the plasma adiponectin, P-selectin, and MDA-LDL levels of 20 diabetic nephropathy patients were explored. The administration of olmesartan and imidapril was safe and did not produce any adverse effects. Adiponectin significantly increased after 12 wk of olmesartan administration. However, subsequently, there was no further increase in the adiponectin level despite combination therapy with imidapril for 12 wk after administration. However, this parameter significantly decreased after 12-wk combination therapy with imidapril. The MDA-LDL level significantly reduced after 12 wk of olmesartan administration. There was no further decrease after 12-wk combination therapy with imidapril. Levels of P-selectin were not significantly decreased for 12 wk olmesartan administration but were significantly decreased after 12-wk combination therapy with imidapril. Data generally indicates that combined therapy with ACEI and ARB has beneficial effects on long-term renal outcome.

After consulting a lot of data, we found that this compound(89396-94-1)Recommanded Product: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Suzuki, Shin; Kamei, Shin-ichiro; Ohgushi, Chie; Mabuchi, Miyako; Kitahora, Haruko; Ikeda, Noriji published an article about the compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride( cas:89396-94-1,SMILESS:O=C([C@H](CN1C)N(C([C@@H](N[C@@H](CCC2=CC=CC=C2)C(OCC)=O)C)=O)C1=O)O.[H]Cl ).Electric Literature of C20H28ClN3O6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:89396-94-1) through the article.

Here, the authors studied the biol. equivalence of imidapril hydrochloride tablet 2.5mg [Taiyo] and tanatril tablets 2.5 on healthy male adults. The results demonstrated the bioequivalence of imidapril hydrochloride tablets and tanatril tablets and the efficacy of imidapril hydrochloride tablets for a clin. use.

After consulting a lot of data, we found that this compound(89396-94-1)Electric Literature of C20H28ClN3O6 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Yoneda, Hikaru; Ueta, Kiichiro; Nagasaki, Masaaki; Arakawa, Kenji published an article about the compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride( cas:89396-94-1,SMILESS:O=C([C@H](CN1C)N(C([C@@H](N[C@@H](CCC2=CC=CC=C2)C(OCC)=O)C)=O)C1=O)O.[H]Cl ).Recommanded Product: 89396-94-1. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:89396-94-1) through the article.

We investigated the renoprotective effects of imidapril hydrochloride ((-)-(4 S)-3-[(2 S)-2-[[(1 S)-1-ethoxycarbonyl-3-phenylpropyl] amino] propionyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, imidapril), an angiotensin-converting enzyme inhibitor, in a diabetic animal model. We used BKS.Cg-+Leprdb/+Leprdb (db/db) mice, a genetic animal model of obese type 2 diabetes. Diabetic db/db mice suffered from glomerular hyperfiltration, albuminuria and hypoalbuminemia. Oral administration of 5 mg/kg/day of imidapril for 3 wk suppressed renal hyperfiltration, reduced albuminuria and normalized hypoalbuminemia. Imidapril did not influence body weights, blood pressure or blood glucose concentrations in db/db mice. Urinary excretion of heparan sulfate (HS) in non-treated 11-wk-old db/db mice was significantly lower than that in age-matched non-diabetic db/+m mice. HS is a component of HS proteoglycans, which are present in glomerular basement membranes and glycocalyx of cell surfaces. Reduced urinary HS excretion indicated glomerular HS loss in db/db mice. Imidapril increased urinary excretion of HS to concentrations observed in db/+m mice, indicating that imidapril prevented the loss of renal HS. These results suggest that imidapril ameliorates renal hyperfiltration and loss of renal contents of HS. Improvement of filtration function and maintenance of HS, which is an important structural component of glomeruli, may contribute to renoprotective effects of imidapril.

After consulting a lot of data, we found that this compound(89396-94-1)Recommanded Product: 89396-94-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Bioequivalence study of imidapril hydrochloride tablet 5mg “”Taiyo””, published in 2008-05-31, which mentions a compound: 89396-94-1, Name is (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, Molecular C20H28ClN3O6, COA of Formula: C20H28ClN3O6.

Here, the authors studied the biol. equivalence of imidapril hydrochloride tablet 5mg [Taiyo] and tanatril tablets 5 (reference product) on healthy male adults. The results demonstrated the bioequivalence of imidapril hydrochloride tablets and tanatril tablets, suggesting a therapeutic efficacy of imidapril hydrochloride tablets.

After consulting a lot of data, we found that this compound(89396-94-1)COA of Formula: C20H28ClN3O6 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Reference of (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, is researched, Molecular C20H28ClN3O6, CAS is 89396-94-1, about Bioequivalence study of imidapril hydrochloride tablet 10mg “”Taiyo””. Author is Suzuki, Shin; Kamei, Shin-ichiro; Ohgushi, Chie; Mabuchi, Miyako; Kitahora, Haruko; Ikeda, Noriji.

Here, the authors studied the equivalent efficacy of imidapril hydrochloride tablet 10mg [Taiyo] and tanatril tablets 10 on healthy male adults. The results demonstrated the bioequivalence of imidapril hydrochloride tablet 10mg [Taiyo] and tanatril tablets for a clin. use.

After consulting a lot of data, we found that this compound(89396-94-1)Reference of (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, is researched, Molecular C20H28ClN3O6, CAS is 89396-94-1, about Is there any association between imidapril hydrochloride stability profile under dry air conditions and cancer initiation?.Application In Synthesis of (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride.

Stability study for imidapril hydrochloride (IMD) was performed under stress conditions of increased temperature (T = 373 K) and decreased relative air humidity (RH = 0%) in order to obtain and identify its degradation product. The degradation sample stored for 15 days under the above environmental conditions was analyzed by LC-MS technique and it was found that the only degradation impurity formed in the course of the investigated drug degradation was IMD diketopiperazine derivative (DKP) which was produced by dehydration and intramol. cyclization. The kinetics of its formation was analyzed by a revalidated RP-HPLC method and the kinetic model of this reaction was established. It was concluded that the DKP formation follows Prout-Tompkins kinetics with the rate constant k ± Δk = 2.034 ± 0.157 × 10-6 [s-1]. The obtained degradation impurity was further assessed with respect to its mutagenic potential using com. Ames MPF 98/100 microplate format mutagenicity assay kit equipped with Salmonella typhimurium strains TA 98 and TA 100. Both strains were exposed to six concentrations (in a range of 0.16-5.0 mg/mL) of DKP in the presence and absence of metabolic activation system. No mutagenic effect was observed confirming that the presence of DKP in IMD final dosage form has no impact on cancer initiation.

Although many compounds look similar to this compound(89396-94-1)Application In Synthesis of (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, numerous studies have shown that this compound(SMILES:O=C([C@H](CN1C)N(C([C@@H](N[C@@H](CCC2=CC=CC=C2)C(OCC)=O)C)=O)C1=O)O.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Quality Control of (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, is researched, Molecular C20H28ClN3O6, CAS is 89396-94-1, about Long-term effect of imidapril hydrochloride compared with dilazep hydrochloride administration on blood pressure and renal function in patients with chronic glomerulonephritis. Author is Satonaka, Hiroshi; Suzuki, Etsu; Hayakawa, Hiroshi; Nishimatsu, Hiroaki; Nagata, Daisuke; Oba, Shigeyoshi; Kamijo, Atsuko; Takeda, Ryo; Takahashi, Masao; Yamamoto, Yuji; Kimura, Kenjiro; Hirata, Yasunobu.

The objective of the present study was to compare the effects of imidapril hydrochloride, an angiotensin converting enzyme inhibitor, and dilazep hydrochloride, an antiplatelet agent, on urinary protein excretion and renal function in patients with chronic glomerulonephritis. Imidapril (2.5 or 5 mg/day) or dilazep (300 or 450 mg/clay) was administered for 3 years. Blood pressure, proteinuria, and renal function were measured before and during the treatment. In the group administered imidapril (n = 11), urinary protein decreased by approx. 50% (2.16 ± 1.57 vs. 0.90 ± 0.53 g/g Cr, P < 0.01) and blood pressure by 14/10 mmHg (139.6 ± 17.4/93.6 ± 8.7 mmHg vs. 122.7 ± 10.5/81.8 ± 9.9 mmHg, P < 0.01) and both remained at low levels during the three years of treatment. No correlation was observed between the extent of blood pressure reduction and changes in urinary protein. Serum creatinine concentrations did not change significantly (1.3 ± 0.3 vs. 1.3 ± 0.3 mg/dL, NS). In the dilazep group (n = 12), there were no significant changes in blood pressure, urinary protein, or serum creatinine. These findings demonstrate that imidapril reduces proteinuria and contributes to preserve renal function, suggesting its usefulness in the treatment of patients with chronic glomerulonephritis. Compounds in my other articles are similar to this one((S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride)Quality Control of (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Akuzawa, Nobuhiro; Nakamura, Tetsuya; Kurashina, Toshiaki; Saito, Yuichiro; Hoshino, Jin; Sakamoto, Hironosuke; Sumino, Hiroyuki; Ono, Zenpei; Nagai, Ryozo published an article about the compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride( cas:89396-94-1,SMILESS:O=C([C@H](CN1C)N(C([C@@H](N[C@@H](CCC2=CC=CC=C2)C(OCC)=O)C)=O)C1=O)O.[H]Cl ).Computed Properties of C20H28ClN3O6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:89396-94-1) through the article.

The authors investigated the ability of the angiotensin converting enzyme (ACE) inhibitor imidapril hydrochloride, and of the calcium channel blocker amlodipine besilate, to prevent nephrosclerosis and left ventricular hypertrophy (LVH) in rats with hypertension induced by chronic inhibition of nitric oxide (NO). Male Wistar rats were given distilled water (control), NG-nitro-L-arginine Me ester (L-NAME) 500 mg/L, L-NAME plus imidapril 10 mg/L or 100 mg/L, or L-NAME plus amlodipine 50 mg/L or 100 mg/L in the drinking water (n = 10-12). 24-H urine samples at 2, 4, and 6 wk were collected, blood samples at 6 wk were obtained, and histol. examined the kidney and heart were performed. L-NAME markedly reduced the levels of NO metabolites in serum and urine while increasing the tail-cuff blood pressure, the urinary albumin level (1.90 ± 0.65 v 0.05 ± 0.02 mg/day/100 g in control), and the area of the left ventricular wall (83.3 ± 3.0 v 69.8 ± 1.8 mm2 in control). Nephrosclerosis and myocardial interstitial fibrosis were documented histol. The plasma renin activity was significantly higher in rats treated with L-NAME than in the control rats. The concomitant administration of imidapril (10 mg/L) with L-NAME completely normalized the tail-cuff pressure, the LVH (70.8 ± 1.8 mm2), the albuminuria (0.05 ± 0.01 mg/day/100 g), and the histol. changes. Amlodipine (50 mg/L) also ameliorated the L-NAME-induced effects, but to a lesser extent. Thus, the chronic inhibition of NO synthesis in rats produced nephrosclerosis and LVH that were effectively prevented by giving imidapril at a dose lower than that of amlodipine. The authors conclude that ACE inhibitors can prevent nephrosclerosis and LVH even in the presence of a reduction in NO production, implying that in rats the inhibition of the renin-angiotensin system is more effective than the blockade of calcium channels in preventing hypertensive tissue injury.

Compounds in my other articles are similar to this one((S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride)Computed Properties of C20H28ClN3O6, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

HPLC of Formula: 89396-94-1. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, is researched, Molecular C20H28ClN3O6, CAS is 89396-94-1, about Antihypertensive effect of TA/6366, a new angiotensin-converting enzyme (ACE) inhibitor in two-kidney, one clip and one-kidney, one clip renovascular hypertensive rats.

Oral administration of TA/6366 (I), a new angiotensin-converting enzyme (ACE) inhibitor, decreased significantly mean arterial pressure in 2-kidney, 1 clip (2K1C) and 1-kidney, 1 clip (1K1C) renovascular hypertensive rats. The antihypertensive effect of I was almost as potent as that enalapril (II), but approx. 5 times more potent than that of captopril (III). The duration of action was almost similar among these 3 ACE inhibitors. The antihypertensive effect of I, II, or III was almost similar between in 2K1C and 1K1C, when they were treated with the same concentration I, II, and III had no substantial effect on the blood pressure in normal control rats. These results suggest that I is a potent antihypertensive agent in not only 2K1C but also 1K1C.

Although many compounds look similar to this compound(89396-94-1)HPLC of Formula: 89396-94-1, numerous studies have shown that this compound(SMILES:O=C([C@H](CN1C)N(C([C@@H](N[C@@H](CCC2=CC=CC=C2)C(OCC)=O)C)=O)C1=O)O.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”