Category: copper-catalyst

[1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride, cas is 578743-87-0, it is a common heterocyclic compound, the copper-catalyst compound, its synthesis route is as follows.,578743-87-0

2-(2-Pyridyl)benzimidazole (78.1 mg, 0.4 mmol) was dissolved in 10 mL of dry THF under N2 and this solution was transferred via cannula to suspension of sodium hydride (17.6 mg, 0.44 mmol, 60% in mineral oil) in dry THF. Reaction mixture was stirred at RT for 1 h and then chloro[l,3-bis(2,6-di-i-propylphenyl)imidazol-2- ylidene]copper(I) (195.1 mg, 0.4 mmol) was added. Reaction mixture was stirred at RT for 3 h. The resulting mixture was filtered through Celite and solvent was removed by rotary evaporation. Recrystallization by vapor diffusion of Et20 into a CH2C12 solution of product gave 154 mg (59.5%>) of dark yellow crystals. Anal, calcd. for C39H44CuN5: C, 72.47; H, 6.86; N, 10.48; Found: C, 72.55; H, 6.94; N, 10.84.

578743-87-0 is used more and more widely, we look forward to future research findings about [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride

Reference£º
Patent; THE UNIVERSITY OF SOUTHERN CALIFORNIA; THOMPSON, Mark; DJUROVICH, Peter; KRYLOVA, Valentina; WO2011/63083; (2011); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Name is 5,10,15,20-Tetraphenyl-21H,23H-porphine copper(II), as a common heterocyclic compound, it belongs to copper-catalyst compound, and cas is 14172-91-9, its synthesis route is as follows.,14172-91-9

(a) N-Bromosuccinimide (0.026 g, 0.148 mmol) was added with stirring in four portions to a solution of 0.02 g (0.0296 mmol) of complex 5 in 10 mL of chloroform. After addition of NBS portion, the reaction mixture was heated under reflux for 5 min. The mixture was cooled, water was added, the organic layer was separated, washed with water, dried with Na2SO4, concentrated to minimal volume, chromatographed on aluminum oxide (using hexane, chloroform-hexane 1 : 2, and then chloroform as eluent), and reprecipitated from ethanol. Yield 0.02 g (0.0202 mmol), 69%. (b) N-Bromosuccinimide (0.0315 g, 0.177 mmol) was added with stirring to a solution of 0.02 g (0.0296 mmol) of complex 5 in a mixture of 10 mL of chloroform and 1 mL of DMF. The reaction mixture was stirred at ambient temperature for 3.5 h. The mixture was treated similarly to method a. Yield 0.021 g (0.0212 mmol), 72%. (c) A mixture of 0.02 g (0.0215 mmol) of porphyrin 3 and 0.038 g (0.215 mmol) of Cu(OAc)2 was dissolved in 10 mL of DMF and the reaction mixture was heated to reflux. The mixture was cooled, poured into water, solid NaCl was added, the precipitate was separated by filtration, washed with water, dried, and chromatographed on aluminum oxide using chloroform as an eluent. Yield 0.018 g (0.0182 mmol), 86%. MS (m/z (Irel, %)): 991 (53) [M]+; for C44H24N4Br4Cu calcd.: 992. IR (nu, cm-1): 2925 s, 2854 m nu(C-H, Ph), 1614 w, 1489 s nu(C=C, Ph), 1466 w, 1457 m nu(C=N), 1367 m, 1351 m nu(C-N), 1193 s, 1169 m, 1145 m, 1039 m delta(C-H, Ph), 1013 m nu(C-C), 862 s, 775 m gamma(C-H, pyrrole ring), 749 m, 693 m gamma(C-H, Ph). For C44H24N4Br4Cu anal. calcd. (%): C, 53.28; N, 5.65; H, 2.44; Br, 32.22. Found (%): C, 53.02; N, 5.53; H, 2.48; Br, 32.08.

With the complex challenges of chemical substances, we look forward to future research findings about 5,10,15,20-Tetraphenyl-21H,23H-porphine copper(II)

Reference£º
Article; Chizhova; Shinkarenko; Zav?yalov; Mamardashvili, N. Zh.; Russian Journal of Inorganic Chemistry; vol. 63; 6; (2018); p. 732 – 735; Zh. Neorg. Khim.; vol. 63; 6; (2018); p. 695 – 699,5;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

It is a common heterocyclic compound, the copper-catalyst compound, [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride, cas is 578743-87-0 its synthesis route is as follows.,578743-87-0

l-(lH-benzimidazol-2-yl)-isoquinoline (46 mg, 0.19 mmol) was dissolved in 10 mL of dry THF under N2 and this solution was transferred via cannula to suspension of sodium hydride (8.36 mg, 0.209 mmol, 60% in mineral oil) in dry THF. The reaction mixture was stirred at RT for 1 h and then chloro[l,3-bis(2,6-di-i-propylphenyl)imidazol-2- ylidene]copper(I) (92.6 mg, 0.19 mmol) was added. The reaction mixture was stirred at RT for 3 h. The resulting mixture was filtered through Celite and solvent was removed by rotary evaporation. Recrystallization by vapor diffusion of Et20 into a CH2C12 solution of product gave 50 mg (38%) of orange crystals.

With the complex challenges of chemical substances, we look forward to future research findings about [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride

Reference£º
Patent; THE UNIVERSITY OF SOUTHERN CALIFORNIA; THOMPSON, Mark; DJUROVICH, Peter; KRYLOVA, Valentina; WO2011/63083; (2011); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

142-71-2, Copper(II) acetate is a copper-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,142-71-2

General procedure: Porphyrins 1-6 (Aldrich, 97%), organic solvents (Merck, 99%), and inorganic salts (Acros, 99%) were used as received. The complex formation was studied by recording electronic absorption spectra of the solutions using a Cary 300 spectrophotometer (Varian). To do so,solutions of the studied porphyrin (2.5¡Á10-5 mol/L)and the salt (2.5¡Á10-3 mol/L) in an organic solvent were put in the cell maintained at constant temperature(¡À0.1C), and the absorbance at the wave length corresponding to the maximum in the spectrum of the formed metal porphyrinate was monitored. Kinetic studies of the complex formation were performed over 288-363 K range.

142-71-2 Copper(II) acetate 8895, acopper-catalyst compound, is more and more widely used in various.

Reference£º
Article; Maltceva; Mamardashvili, N. Zh.; Russian Journal of General Chemistry; vol. 87; 6; (2017); p. 1175 – 1183; Zh. Obshch. Khim.; vol. 87; 6; (2017); p. 955 – 963,8;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14172-91-9,5,10,15,20-Tetraphenyl-21H,23H-porphine copper(II),as a common compound, the synthetic route is as follows.,14172-91-9

Cu(II)TPP (3) (0.7 g, 1.0 mmol)was dissolved in chloroform (700 mL) and acetic acid (15 mL) was added. Cu(NO3)2¡¤3H2O (0.63 g,2.6 mmol) was dissolved in acetic anhydride (70 mL) and added to the reaction mixture. The mixturewas heated to 35 C and let to stir for 5 h. The reaction mixture was washed with water(3 ¡Á 700 mL), saturated K2CO3 solution (2 ¡Á 700 mL) and again with water (2 ¡Á 700 mL), dried overanhydrous Na2SO4 and solvents removed by azeotropic evaporation with methanol. The residue waspurified by column chromatography using CH2Cl2:pentane 1:1 as eluent resulting in Cu(II)TPPNO2(4) as a dark purple solid (0.65 g, 0.89 mmol, 89%)

As the paragraph descriping shows that 14172-91-9 is playing an increasingly important role.

Reference£º
Article; Blom, Magnus; Norrehed, Sara; Andersson, Claes-Henrik; Huang, Hao; Light, Mark E.; Bergquist, Jonas; Grennberg, Helena; Gogoll, Adolf; Molecules; vol. 21; 1; (2016);,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belongs to copper-catalyst compound, name is Cuprouschloride, and cas is 7758-89-6, its synthesis route is as follows.,7758-89-6

Step 3. 3,3-Ethylenedioxy-5alpha-hydroxy-11beta-[4-(N,N-dimethylamino)phenyl]-17beta-cyano-17alpha-trimethylsilyloxyestr-9(10)-ene (4): Magnesium (2.6 g, 107 mmol) was added to a 1.0 L, 3-neck flask equipped with a magnetic stir bar, addition funnel and a condenser. A crystal of iodine was added followed by dry THF (100 mL) and a few drops of 1,2-dibromoethane. The mixture was stirred under nitrogen and heated in a warm water bath until evidence of reaction was observed. A solution of 4-bromo-N,N-dimethylaniline (19.6 g, 98 mmol) in dry THF (100 mL) was then added dropwise over a period of 20 min. and the mixture stirred for an additional 1.5 hours. Solid copper (I) chloride (1 g, 10.1 mmol) was added followed 30 minutes later by a solution of the 5alpha-,10alpha-epoxide (3, 8.4 g, 19.55 mmol) in dry THF (10 mL). The mixture was stirred at room temperature for 1 hr., then quenched by the addition of saturated NH4Cl solution (100 mL). With vigorous stirring, air was drawn through the reaction mixture for 30 minutes. The mixture was diluted with ether (250 mL) and the layers allowed to separate. The THF/ether solution was washed with 10% NH4Cl solution (3*), 2 N NH4OH solution (3*) and brine (1*). The organic layers were combined, dried over Na2SO4, filtered and concentrated in vacuo to give the crude product. Crystallization of the crude product from ether gave 8.6 g of the pure product 4 as a white solid in 80% yield; m.p.=222-224 C. dec. FTIR (KBr, diffuse reflectance) numax 3221, 2951, 2232, 1613, 1517 and 1253 cm-1. NMR (CDCl3) delta 0.20 (s, 9H, OSiMe3), 0.5 (s, 3H, C18-CH3), 2.83 (s, 6H, NMe2), 3.9 (m, 4H, OCH2CH2O), 4.3 (m, 1H, C11alpha-CH), 6.63 (d, J=9 Hz, 2H, 3′,5′ aromatic-CH’s) and 7.03 (d, J=9 Hz, 2′,6′ aromatic-CH’s).

With the complex challenges of chemical substances, we look forward to future research findings about 7758-89-6,belong copper-catalyst compound

Reference£º
Patent; The United States of America as represented by the Department of Health and Human Services; US6900193; (2005); B1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”