Category: copper-catalyst

A common heterocyclic compound, the copper-catalyst compound, name is Copper(II) sulfate pentahydrate,cas is 7758-99-8, mainly used in chemical industry, its synthesis route is as follows.

[0146] Sodium nitrite (2.35 g, 34.13mmol) solution (40 mL) was added dropwise to 4- Chloro-2-fluoro aniline (4. [5G,] 31mmol) in 170 mL HBr [AT-10C] bath temperature, then the mixture was stirred for 30 min at-10C bath temperature. In parallel, copper sulfate (10.22g, 24. [29MMOL)] and sodium bromide (3.79 g, 36. [8MMOL)] were mixed and the reaction mixture was heated at [60C] for 30 min. Then sodium sulfite (2.66g, 21. [2MMOL)] was added into this copper sulfate reaction mixture and heated for [95C] for 30 min. The reaction mixture was cooled to room temperature and solid formed was washed with water to afford white solid cuprous bromide. The diazonium salt was portion wise added into the freshly prepared cuprous bromide in 40 mL HBr [AT-10C] bath temperature and the reaction mixture was then warmed to room temperature. The reaction mixture was heated at [55C] for 20 min, cooled and then extracted with ethyl acetate three times. The combined organic layer was washed with water and saturated brine solution, dried over sodium sulfate and concentrated. The crude material was purified by column chromatography (5: 95 ethyl acetate: pet ether) to afford solid product.

As the rapid development of chemical substances, we look forward to future research findings about 7758-99-8

Reference£º
Patent; CHEMOCENTRYX, INC.; WO2003/105853; (2003); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

[1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride, cas is 578743-87-0, it is a common heterocyclic compound, the copper-catalyst compound, its synthesis route is as follows.

In a dry double-mouth bottle to place Ir – 3 (0.0796 g, 0.1 mmol), CuClNHC (0.0488 g, 0.1 mmol), vacuum pumping and nitrogen cycle three times, then the nitrogen flow by adding 10 ml ethanol, stirring reflux reaction for 4 hours, cooling to room temperature, then added potassium hexafluorophosphate (0.184 g, 1 mmol), stirring at the room temperature reaction 2 hours, filtered, concentrated filtrate, ethanol: dichloromethane=1:10 column, get the orange solid 0.069 g, and the yield is 50%.

As the rapid development of chemical substances, we look forward to future research findings about 578743-87-0

Reference£º
Patent; Jiangsu University Of Science And Technology; Shi Chao; Li Qiuxia; Zhang Xinghua; (24 pag.)CN108690096; (2018); A;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.578743-87-0,[1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride,as a common compound, the synthetic route is as follows.

In a dry double-mouth bottle to place Ir – 2 (0.0796 g, 0.1 mmol), CuClNHC (0.0488 g, 0.1 mmol), vacuum pumping and nitrogen cycle three times, then the nitrogen flow by adding 10 ml ethanol, stirring reflux reaction for 4 hours, cooling to room temperature, then added potassium hexafluorophosphate (0.184 g, 1 mmol), stirring at the room temperature reaction 2 hours, filtered, concentrated filtrate, ethanol: dichloromethane=1:10 column, get the orange solid 0.069 g, and the yield is 50%.

As the paragraph descriping shows that 578743-87-0 is playing an increasingly important role.

Reference£º
Patent; Jiangsu University Of Science And Technology; Shi Chao; Li Qiuxia; Zhang Xinghua; (24 pag.)CN108690096; (2018); A;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

[1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride, cas is 578743-87-0, it is a common heterocyclic compound, the copper-catalyst compound, its synthesis route is as follows.

Chloro[l,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I) (195.1 mg, 0.4 mmol) and silver triflate (102.7 mg, 0.4 mmol) were mixed under nitrogen in 25 mL flask and 10 mL of dry THF were added. Reaction mixture was stirred at RT for 30 minutes.Solution of 2,2′-bipyridine (62.4 mg, 0.4 mmol) in dry THF (5 mL) was added. Reaction mixture turned orange and was stirred at RT overnight. Resulting mixture was filtered through Celite and solvent was evaporated on rotovap. Recrystallization from CH2CI2 by vapor diffusion of EtaO gave 215 mg (70.9%) of orange crystals. Anal, calcd. forC38H44CUF3N4O3S: C, 60.26; H, 5.86; N, 7.40; Found: C, 60.18; H, 5.82; N, 7.38. Structure was confirmed by iH-NMR spectrum of [(IPR)Cu(bipy)]OTf (CDCb, 400MHz).

As the rapid development of chemical substances, we look forward to future research findings about 578743-87-0

Reference£º
Patent; THE UNIVERSITY OF SOUTHERN CALIFORNIA; THOMPSON, Mark; DJUROVICH, Peter; KRYLOVA, Valentina; WO2011/63083; (2011); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Bis(8-quinolinolato)copper(II), cas is 10380-28-6, it is a common heterocyclic compound, the copper-catalyst compound, its synthesis route is as follows.

General procedure: To a mixture of K3PO4 (18.8 g, 88.7 mmol), CuII oxinate (780 mg,2.22 mmol), KI (3.68 g, 22.2 mmol) and 2 (10.0 g, 22.2 mmol), water(30 mL) and acetonitrile (30 mL) were added. The mixture was stirredat 120 C for 3 days. Then brine was added, and the mixture was extracted with EA. The combined organic layers were dried with anhydrous MgSO4 and concentrated under reduced pressure. The residue was purified on a silica gel column with PE:DCM (3:1) as eluent to give3 (3.27 g, 51%) as a white solid. 1H NMR (400 MHz, CDCl3): delta (ppm)7.53 (d, J=8.8 Hz, 1H), 7.39 (d, J=8.0 Hz, 1H), 7.29 (t, J=8.4 Hz,1H), 7.11 (d, J=8.0 Hz, 1H), 7.03 (s, 1H), 6.98 (t, J=7.4 Hz, 1H),6.88 (d, J=8.0 Hz, 1H), 6.34 (d, J=7.2 Hz, 1H), 6.23 (d, J=7.6 Hz,1H). 13C NMR (125 MHz, CDCl3): delta (ppm) 161.1, 160.1, 131.7, 130.5,127.7, 126.7, 125.0, 124.5, 124.0, 121.5, 114.6, 111.0, 87.7, 85.8.Anal. Calcd for C14H9BrO2 (%): C, 58.16; H, 3.14; Br, 27.64; O, 11.07;Found: C, 58.03; H, 3.02; O, 10.98.

With the rapid development of chemical substances, we look forward to future research findings about 10380-28-6

Reference£º
Article; He, Keqiang; Li, Weili; Tian, Hongkun; Zhang, Jidong; Yan, Donghang; Geng, Yanhou; Wang, Fosong; Organic electronics; vol. 57; (2018); p. 359 – 366;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

5,10,15,20-Tetraphenyl-21H,23H-porphine copper(II), cas is 14172-91-9, it is a common heterocyclic compound, the copper-catalyst compound, its synthesis route is as follows.

Copper(II) meso-tetra(4-carboxyphenyl)porphine (8.8 mg, 0.01 mmol) and fumaric acid (9.9 mg, 0.06 mmol) were dissolved in DMF (5 mL) in a small capped vial, sonicated to ensure homogeneity and heated to 80 C for 72 h, followed by 72 h of evaporation in a crystallizing dish, yielding diffraction quality fibrous red crystals. numax/cm-1: 3403 (C(sp2)H), 2770 (OH), 1390-1280 (C=O). 1600-1450 (CC), 1320 (CO), 1380 (CN), 1006 (CuTCPP), 790-600 (CH). Found: C, 59.91; H, 5.17; N, 9.54; O, 18.40. Calc. for C66H68CuN10O14: C, 61.50; H, 5.32; N, 10.87; O, 17.38.

With the rapid development of chemical substances, we look forward to future research findings about 14172-91-9

Reference£º
Article; Fidalgo-Marijuan, Arkaitz; Amayuelas, Eder; Barandika, Gotzone; Bazan, Begona; Urtiaga, Miren Karmele; Arriortua, Maria Isabel; Molecules; vol. 20; 4; (2015); p. 6683 – 6699;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Bis(acetylacetone)copper, cas is 13395-16-9, it is a common heterocyclic compound, the copper-catalyst compound, its synthesis route is as follows.

A yellow solution of H4L (0.30mmol, 0.068g) in dmf (6mL) was added to a turquoise solution of Cu(acac)2 (0.30mmol, 0.079g) in dmf (20mL). The immediately formed green solution was refluxed for 3h and left for slow evaporation. X-ray quality blue crystals of 3¡¤1.5dmf were formed after 2months, which were filtered off and dried under vacuum. (Yield: 0.053g, ?60%). The solid was analyzed as solvent free. C44H56Cu4N4O18 requires: C, 44.67; H, 4.77; N, 4.73%. Found: C, 44.49; H, 4.74; N, 4.70. FT-IR (KBr pellets, cm-1): 3553(s), 3477(s), 3414(s), 1638(s), 1617(vs), 1578(s), 1553(s), 1533(s), 1462(w), 1413(m), 1384(m), 1355(s), 1275(s), 1189(s), 1020(s), 937(s), 782(s), 684(m), 653(w), 613(s), 480(m), 455(s).

With the rapid development of chemical substances, we look forward to future research findings about 13395-16-9

Reference£º
Article; Lazarou, Katerina N.; Savvidou, Aikaterini; Raptopoulou, Catherine P.; Psycharis, Vassilis; Polyhedron; vol. 152; (2018); p. 125 – 137;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Bis(acetylacetone)copper, cas is 13395-16-9, it is a common heterocyclic compound, the copper-catalyst compound, its synthesis route is as follows.

A mixture of 1.05 g (4 mmol) Cu(AcAc)2, 0.44 g (2 mmol) Zn(OAc)2, 0.38 g (2 mmol) SnCl2, and 20 ml OLA were added into a 100 ml three-neck round-bottom reaction flask connected to a nitrogen gas cylinder. The mixture solution was always stirred vigorously in the flask purged with high pure N2 gas (99.999%), during the whole synthesis. After heated at 130 C for 30 min, the mixture solution became brownish. The brownish solution was injected with 8 ml of sulfur – OLA solution (1 M), then heated at the reaction temperature T reaction 240-280 C for 1 h. When its color changed from dark brownish into blackish, the mixture solution (or product) was cooled down to room temperature (RT) and added with 15 ml of toluene for dispersing by sonication. To washing or purifying the product, 40 ml of ethanol was firstly added to let the nanoparticles flocculate and precipitate; then precipitates of nanoparticles were collected by centrifuging at 4000 rpm for 20 min and the supernatant liquid was removed; the collected precipitates were dispersed in toluene again by sonication; then ethanol was added for precipitates, new precipitates were collected again by centrifuging. The above process was repeated for three times. The final precipitates (or CZTS nanoparticles) were divided into two parts: (1) CZTS nanoparticles dispersed in toluene to form a stable ink solution and (2) CZTS power dried in a vacuum oven.

With the rapid development of chemical substances, we look forward to future research findings about 13395-16-9

Reference£º
Article; Zhou, Min; Gong, Yanmei; Xu, Jian; Fang, Gang; Xu, Qingbo; Dong, Jianfeng; Journal of Alloys and Compounds; vol. 574; (2013); p. 272 – 277;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.578743-87-0,[1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride,as a common compound, the synthetic route is as follows.

l-(lH-benzimidazol-2-yl)-isoquinoline (46 mg, 0.19 mmol) was dissolved in 10 mL of dry THF under N2 and this solution was transferred via cannula to suspension of sodium hydride (8.36 mg, 0.209 mmol, 60% in mineral oil) in dry THF. The reaction mixture was stirred at RT for 1 h and then chloro[l,3-bis(2,6-di-i-propylphenyl)imidazol-2- ylidene]copper(I) (92.6 mg, 0.19 mmol) was added. The reaction mixture was stirred at RT for 3 h. The resulting mixture was filtered through Celite and solvent was removed by rotary evaporation. Recrystallization by vapor diffusion of Et20 into a CH2C12 solution of product gave 50 mg (38%) of orange crystals.

578743-87-0 [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride 0, acopper-catalyst compound, is more and more widely used in various.

Reference£º
Patent; THE UNIVERSITY OF SOUTHERN CALIFORNIA; THOMPSON, Mark; DJUROVICH, Peter; KRYLOVA, Valentina; WO2011/63083; (2011); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

The copper-catalyst compound, cas is 7758-89-6 name is Cuprouschloride, mainly used in chemical industry, its synthesis route is as follows.

Step 5. 3,3-Ethylenedioxy-5alpha-hydroxy-11beta-[4-(N,N-dimethylamino)phenyl]-17alpha-trimethylsilyloxy-21-methyl-19-norpregn-9(10)-en-20-one (25): Mg (2.80 g, 116.2 mmol), which was washed with 0.1 N HCl, then H2O and acetone and dried in vacuo, was weighed into dry round-bottomed flask equipped with a reflux condenser. A small crystal of iodine was added and the system was flushed with nitrogen and flame-dried. The flask was cooled to room temperature and 68.5 mL of THF distilled from LAH was added via syringe. 1,2-Dibromoethane (approx. 0.5 mL) was added and the mixture was stirred at room temperature. After bubbling began and the color of I2 disappeared, a solution of 4-bromo-N,N-dimethylaniline (20.43 g, 102.1 mmol) in THF (34 mL) was added via syringe. The mixture was stirred until most the Mg had reacted. Copper (I) chloride (1.13 g, 114.2 mmol) was added as a solid and stirred for 20 min. The crude epoxide (24) (7.33 g, 15.91 mmol) in THF (49 mL) was then added using a syringe. The reaction mixture was stirred at room temperature for 30 min, at which time the reaction was complete by TLC (2% acetone/CH2Cl2). Saturated NH4Cl solution (25 mL) was added and stirred for 30 min while air was pulled through by slight vacuum. The mixture was diluted with H2O, extracted with CH2Cl2 (3*), washed with H2O (2*) and brine, dried over Na2SO4, and evaporated under reduced pressure. The residue was purified by flash chromatography using 3% acetone/CH2Cl2) to afford 4.27 g of the pure product (25) in 46.1% yield. IR (KBr, diffuse reflectance) numax 3531, 2940, 1708, 1614, and 1518 cm-1. NMR (CDCl3) delta 0.09 (s, 9H, Si(CH3)3), 0.19 (s, 3H, C18-CH3), 1.02 (t, J=7 Hz, 3H, C21-CH3), 2.88 (s, 6H, N(CH3)2), 3.99 (m, 4H, C3-OCH2CH2O-), 4.26 (br d, 1 H, C11alpha-CH), 6.85 (dd, J=41 Hz, J’=10 Hz, 4H, aromatic-CH). MS (EI) m/z (relative intensity): 581 (M+, 46), 563(34), 391 (37), 134(65) and 121 (100).

With the rapid development of chemical substances, we look forward to future research findings about 7758-89-6

Reference£º
Patent; The United States of America as represented by the Department of Health and Human Services; US6900193; (2005); B1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”