Category: copper-catalyst

The copper-catalyst compound, cas is 6046-93-1 name is Copper(II) acetate hydrate, mainly used in chemical industry, its synthesis route is as follows.

Bis(8-quinolinolato)copper(II) was synthesized as follows. In a typical synthesis, 1.45 g (10 mmol) of 8-quinolinol ligand was dissolved in 20 ml THF, followed by the dropwise addition of a solution of 1.0 g (5 mmol) Cu(CH3COO)2*H2O in 10ml THF at reflux temperature. The resultant solution was stirred and refluxed for 2 h. After cooling, the solid product was separated by filtration and denoted as CuQ2.

As the rapid development of chemical substances, we look forward to future research findings about 6046-93-1

Reference£º
Article; Hu, Jing; Zou, Yongcun; Liu, Jing; Sun, Jian; Yang, Xiaoyuan; Kan, Qiubin; Guan, Jingqi; Research on Chemical Intermediates; vol. 41; 8; (2015); p. 5703 – 5712;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

The copper-catalyst compound, cas is 142-71-2 name is Copper(II) acetate, mainly used in chemical industry, its synthesis route is as follows.

0.118 g (0.65 mmol) of Cu(OAc)2 was added to a solution of 0.04 g (0.065 mmol)of 2 in 50 mL of DMF. The reaction mixture was refluxed during 2 min and cooled to ambient; five-fold excess of water and NaCl was added. The precipitate was filtered off, washed with water, and dried. Yield 0.04 g (0.059 mmol) of CuTPP.

As the rapid development of chemical substances, we look forward to future research findings about 142-71-2

Reference£º
Article; Maltseva; Zvezdina; Chizhova; Mamardashvili, N. Zh.; Russian Journal of General Chemistry; vol. 86; 1; (2016); p. 102 – 109; Zh. Obshch. Khim.; vol. 86; 1; (2016); p. 110 – 117,8;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

The copper-catalyst compound, name is Copper(II) acetate hydrate,cas is 6046-93-1, mainly used in chemical industry, its synthesis route is as follows.

A mixed solvent of 75 ml of chlorobenzene and 50 ml of N,N-dimethylformamide (DMF) was added to a 250 ml three-neck distillation flask. Add 5,10,15,20-tetraphenylporphyrin (H2TPP) (0.50 g, 0.81 mmol) start stirring, after the solid is dissolved, add an appropriate amount of copper acetate monohydrate (Cu(OAc)2*H2O) (0.324 g 1.62 mmol). Put about 3g of potassium carbonate (K2CO3) in the alkali storage chamber, the mixture in the reaction kettle was heated to 150 C and kept under reflux. The progress of the reaction (UV-Vis) is monitored by thin layer chromatography (TLC) or ultraviolet visible absorption spectroscopy until the complete reaction of H2TPP is completed. The solvent is distilled off under vacuum. The remaining solid was dissolved in 150 ml of chloroform. Wash three times with 50 ml of water each time, then collect these liquids in a static layer. The organic layer was further washed three times with 50 ml of saturated sodium bicarbonate solution. Then dried with potassium sulfate (K2SO4), The solvent is distilled off under vacuum. The remaining solid was recrystallized from chloroform/heptane. A purple crystalline solid product of 0.526 g was obtained in a yield of 96%.

As the rapid development of chemical substances, we look forward to future research findings about 6046-93-1

Reference£º
Patent; Guangzhou Lvying Environmental Protection Technology Co., Ltd.; Yao Shu; Chen Liangming; Qiao Nasen¡¤wudong; (8 pag.)CN109651381; (2019); A;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

The copper-catalyst compound, name is Bis(acetylacetone)copper,cas is 13395-16-9, mainly used in chemical industry, its synthesis route is as follows.

General procedure: The monodisperse CuPd alloy NPs with composition controlwere synthesized by using a modified version of our estab-lished recipe for the CoPd alloy NPs [14]. In a typical synthesis of Cu75Pd25NPs, copper(II) acetylacetonate (0.35 mmol, 90 mg)and palladium(II) acetylacetonate (0.1 mmol, 31 mg) were dis-solved in 3 mL of OAm in a 10 mL of glass vial. In a four-necked glass reactor that allows to study under inert atmosphere,200 mg of MB was dissolved in 3 mL of OAm and 7 mL of 1-octadecene at 80C under magnetic stirring. Next, the metal precursor mixture was quickly injected into the reactor under argon environment. The reaction was then proceed for 1 h before cooled down to room temperature. Then, the colloidal NPs mixture was transferred into two separate centrifuge tubeand acetone/ethanol (v/v = 7/3) was added into the tubes. TheNP product was separated by centrifugation at 8500 rpm for10 min.

As the rapid development of chemical substances, we look forward to future research findings about 13395-16-9

Reference£º
Article; Guengoermez, Kuebra; Metin, Oender; Applied Catalysis A: General; vol. 494; (2015); p. 22 – 28;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7758-89-6,Cuprouschloride,as a common compound, the synthetic route is as follows.

Step 3. 3,3-Ethylenedioxy-5alpha-hydroxy-11beta-[4-(N,N-dimethylamino)phenyl]-17beta-cyano-17alpha-trimethylsilyloxyestr-9(10)-ene (4): Magnesium (2.6 g, 107 mmol) was added to a 1.0 L, 3-neck flask equipped with a magnetic stir bar, addition funnel and a condenser. A crystal of iodine was added followed by dry THF (100 mL) and a few drops of 1,2-dibromoethane. The mixture was stirred under nitrogen and heated in a warm water bath until evidence of reaction was observed. A solution of 4-bromo-N,N-dimethylaniline (19.6 g, 98 mmol) in dry THF (100 mL) was then added dropwise over a period of 20 min. and the mixture stirred for an additional 1.5 hours. Solid copper (I) chloride (1 g, 10.1 mmol) was added followed 30 minutes later by a solution of the 5alpha-,10alpha-epoxide (3, 8.4 g, 19.55 mmol) in dry THF (10 mL). The mixture was stirred at room temperature for 1 hr., then quenched by the addition of saturated NH4Cl solution (100 mL). With vigorous stirring, air was drawn through the reaction mixture for 30 minutes. The mixture was diluted with ether (250 mL) and the layers allowed to separate. The THF/ether solution was washed with 10% NH4Cl solution (3*), 2 N NH4OH solution (3*) and brine (1*). The organic layers were combined, dried over Na2SO4, filtered and concentrated in vacuo to give the crude product. Crystallization of the crude product from ether gave 8.6 g of the pure product 4 as a white solid in 80% yield; m.p.=222-224 C. dec. FTIR (KBr, diffuse reflectance) numax 3221, 2951, 2232, 1613, 1517 and 1253 cm-1. NMR (CDCl3) delta 0.20 (s, 9H, OSiMe3), 0.5 (s, 3H, C18-CH3), 2.83 (s, 6H, NMe2), 3.9 (m, 4H, OCH2CH2O), 4.3 (m, 1H, C11alpha-CH), 6.63 (d, J=9 Hz, 2H, 3′,5′ aromatic-CH’s) and 7.03 (d, J=9 Hz, 2′,6′ aromatic-CH’s).

As the paragraph descriping shows that 7758-89-6 is playing an increasingly important role.

Reference£º
Patent; The United States of America as represented by the Department of Health and Human Services; US6900193; (2005); B1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

7758-89-6, Cuprouschloride is a copper-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 1 N2-(4-Bromophenyl)-5-trifluoromethyl-1,3-benzoxazol-2-amine 4-Bromophenyl isothiocyanate (1.667 g, 7.785 mmol) was added to a solution of 2-amino-4-trifluoromethylphenol (1.379 g, 7.785 mmol) in tetrahydrofuran (THF) (100 mL) and the reaction was stirred at room temperature for about 16 hours then at about 50 C. for about another 5 hours. Copper (I) chloride (0.771 g, 7.785 mmol) and triethylamine (1.08 mL, 7.785 mmol) were added, and the mixture was stirred at room temperature for about 72 hours and then at about 50 C. for about another 18 hours. Additional copper (I) chloride (0.385 g) was added and the reaction was stirred at about 60 C. for about another 2 hours. The reaction was concentrated under reduced pressure, dissolved in methanol (200 mL), filtered through a pad of diatomaceous earth and the solvent removed in vacuo to afford N2-(4-bromophenyl)-5-trifluoromethyl-1,3-benzoxazol-2-amine as a brown solid (3.90 g, 140% of theory); RP-HPLC Rt 17.627 min, 77% purity (5% to 85% acetonitrile/0.1M aqueous ammonium acetate, buffered to pH 4.5, over 20 min at 1 mL/min; lambda=254 nm; Waters Deltapak C18, 300 A, 5 mum, 150*3.9 mm column); and m/z 354.9 and 356.9 (M-H)-.

As the paragraph descriping shows that 7758-89-6 is playing an increasingly important role.

Reference£º
Patent; Wishart, Neil; Rudolph, Alena; Ritter, Kurt; US2003/109714; (2003); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

7758-89-6, Cuprouschloride is a copper-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 5. 3,3-Ethylenedioxy-5alpha-hydroxy-11beta-[4-(N,N-dimethylamino)phenyl]-17alpha-trimethylsilyloxy-21-methyl-19-norpregn-9(10)-en-20-one (25): Mg (2.80 g, 116.2 mmol), which was washed with 0.1 N HCl, then H2O and acetone and dried in vacuo, was weighed into dry round-bottomed flask equipped with a reflux condenser. A small crystal of iodine was added and the system was flushed with nitrogen and flame-dried. The flask was cooled to room temperature and 68.5 mL of THF distilled from LAH was added via syringe. 1,2-Dibromoethane (approx. 0.5 mL) was added and the mixture was stirred at room temperature. After bubbling began and the color of I2 disappeared, a solution of 4-bromo-N,N-dimethylaniline (20.43 g, 102.1 mmol) in THF (34 mL) was added via syringe. The mixture was stirred until most the Mg had reacted. Copper (I) chloride (1.13 g, 114.2 mmol) was added as a solid and stirred for 20 min. The crude epoxide (24) (7.33 g, 15.91 mmol) in THF (49 mL) was then added using a syringe. The reaction mixture was stirred at room temperature for 30 min, at which time the reaction was complete by TLC (2% acetone/CH2Cl2). Saturated NH4Cl solution (25 mL) was added and stirred for 30 min while air was pulled through by slight vacuum. The mixture was diluted with H2O, extracted with CH2Cl2 (3*), washed with H2O (2*) and brine, dried over Na2SO4, and evaporated under reduced pressure. The residue was purified by flash chromatography using 3% acetone/CH2Cl2) to afford 4.27 g of the pure product (25) in 46.1% yield. IR (KBr, diffuse reflectance) numax 3531, 2940, 1708, 1614, and 1518 cm-1. NMR (CDCl3) delta 0.09 (s, 9H, Si(CH3)3), 0.19 (s, 3H, C18-CH3), 1.02 (t, J=7 Hz, 3H, C21-CH3), 2.88 (s, 6H, N(CH3)2), 3.99 (m, 4H, C3-OCH2CH2O-), 4.26 (br d, 1 H, C11alpha-CH), 6.85 (dd, J=41 Hz, J’=10 Hz, 4H, aromatic-CH). MS (EI) m/z (relative intensity): 581 (M+, 46), 563(34), 391 (37), 134(65) and 121 (100).

The synthetic route of 7758-89-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; The United States of America as represented by the Department of Health and Human Services; US6900193; (2005); B1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7758-99-8,Copper(II) sulfate pentahydrate,as a common compound, the synthetic route is as follows.

Example 2828.1 28.2[0329] Methyl 4-bromo-3-(trifluoromethoxy)benzoate (28.2). To a solution of 4-amino-3-(trifluoromethoxy)benzoic acid (2.00 g, 9.10 mmol) in MeOH (25.0 mL), was slowly added HCl (1.0 mL, 1.0 M in ether) at room temperature. The resulting reaction mixture was stirred at room temperature overnight. Benzene (20 mL) was added, and the reaction was heated at reflux with a Dean-Stark trap to remove the half volume of the solvent. The rest of the solvent was then evaporated to give the product. MS (ESI) m/e = 235.9 [M+l]+, Calc’d for CgHeF3NOs, 235.1. The crude product was used in the next step without further purification. To an ice-cooled suspension of methyl 4-amino-3- (trifluoromethoxy)benzoate hydrogen chloride salt (8.60 g, 31.70 mmol) in 17.1 mL of water and concentrated HBr (48 %, 17.1 mL), was slowly added a prepared 2.5 M solution of sodium nitrite (2.20 g in 12.7 mL) at 00C. The reaction mixture was stirred at 0 0C for 10 minutes. Meanwhile, a solution OfCuSO4 (6.68 g) in 35 mL of water was heated and sodium bromide (6.52 g) was added. The solution became a green color, and a solution OfNa2SOs (2.80 g) in water (10 mL) was then added to it. The solution was cooled at 0 0C and washed with water (25 x 3 mL). The water was then decanted off. Concentrated HBr (16.7 mL) was added, and the solution became a purple color. The solution of CuBr was slowly added to the diazonium salt (prepared above) at 00C. After addition, the ice-bath was removed, and an oil-bath was placed under the reaction vessel. The reaction mixture was then heated to 600C for 15 minutes, at 80 0C for 15 minutes, and then at 1000C for 20 minutes. The reaction mixture was next cooled to room temperature and made basic with Na2CO3 to a pH 8. The aqueous solution was extracted with EtOAc (100 x 2 mL). The organic layer was washed with brine (25 mL) and dried with MgSO4. The solvent was removed to give the crude product 28.2. 1H NMR (CDCl3) delta 3.96 (s, 3H), 7.75 (d, J= 8.4 Hz5 1 H), 7.86 (d, J= 8.4 Hz, 1 H), 7.98 (s, IH).

The synthetic route of 7758-99-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; WO2008/30520; (2008); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

6046-93-1, Copper(II) acetate hydrate is a copper-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a 250mL distillation flask, 5,10,15,20-tetraphenylporphyrin (H2TPP) (0.50g, 0.81mmol) and NaOAc (0.30g, 3.6mmol) was stirred in 75mL of chlorobenzene and 50mL of DMF. After the addition of two equivalents of metal acetate, a Soxhlet extractor with a cellulose filter thimble filled with ?3g of K2CO3 was attached to the distillation flask. The assembly was completed with a condenser on the top of the extractor; and then the mixture was heated to reflux at 150C overnight. The reaction extent was monitored by TLC or UV-Vis until all the H2TPP was consumed. After the reaction was compete, the solvent was removed under vacuum. The remaining solid was dissolved in 150mL of chloroform, and washed with water (50mL¡Á3). The organic layer was further washed with a saturated sodium bicarbonate solution (50mL¡Á3), and then dried over K2SO4. After removal of the solvent in vacuo, the solid was recrystallized from chloroform/heptane.

The synthetic route of 6046-93-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yao, Shu A.; Hansen, Christopher B.; Berry, John F.; Polyhedron; vol. 58; (2013); p. 2 – 6;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6046-93-1,Copper(II) acetate hydrate,as a common compound, the synthetic route is as follows.

Bis(8-quinolinolato)copper(II) was synthesized as follows. In a typical synthesis, 1.45 g (10 mmol) of 8-quinolinol ligand was dissolved in 20 ml THF, followed by the dropwise addition of a solution of 1.0 g (5 mmol) Cu(CH3COO)2*H2O in 10ml THF at reflux temperature. The resultant solution was stirred and refluxed for 2 h. After cooling, the solid product was separated by filtration and denoted as CuQ2.

As the paragraph descriping shows that 6046-93-1 is playing an increasingly important role.

Reference£º
Article; Hu, Jing; Zou, Yongcun; Liu, Jing; Sun, Jian; Yang, Xiaoyuan; Kan, Qiubin; Guan, Jingqi; Research on Chemical Intermediates; vol. 41; 8; (2015); p. 5703 – 5712;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”