Related Products of 492-27-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-Hydroxyquinoline-2-carboxylic Acid, is researched, Molecular C10H7NO3, CAS is 492-27-3, about Tryptophan levels associate with incident cardiovascular disease in chronic kidney disease.
Background. Non-traditional risk factors like inflammation and oxidative stress play an essential role in the increased cardiovascular disease (CVD) risk prevalent in chronic kidney disease (CKD). Tryptophan catabolism by the kynurenine pathway (KP) is linked to systemic inflammation and CVD in the general and dialysis population. However, the relationship of KP to incident CVD in the CKD population is unknown. Methods. We measured tryptophan metabolites using targeted mass spectrometry in 92 patients with a history of CVD (old CVD); 46 patients with no history of CVD and new CVD during follow-up (no CVD); and 46 patients with no CVD history who developed CVD in the median follow-up period of 2 years (incident CVD). Results. The three groups are well-matched in age, gender, race, diabetes status and CKD stage, and only differed in total cholesterol and proteinuria. Tryptophan and kynurenine levels significantly decreased in patients with ′Incident CVD′ compared with the no CVD or old CVD groups (P=5.2E-7; P=0.003 resp.). Kynurenic acid, 3-hydroxykynurenine and kynurenine are all increased with worsening CKD stage (P<0.05). An increase in tryptophan levels at baseline was associated with 0.32-fold lower odds of incident CVD (P=0.000014) compared with the no CVD group even after adjustment for classic CVD risk factors. Addition of tryptophan and kynurenine levels to the receiver operating curve constructed from discriminant anal. predicting incident CVD using baseline clin. variables increased the area under the curve from 0.76 to 0.82 (P=0.04). Conclusions. In summary, our study demonstrates that low tryptophan levels are associated with incident CVD in CKD. There are many compounds similar to this compound(492-27-3)Related Products of 492-27-3. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.
Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”