Formula: C10H7NO3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-Hydroxyquinoline-2-carboxylic Acid, is researched, Molecular C10H7NO3, CAS is 492-27-3, about Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period. Author is Tuka, Bernadett; Nyari, Aliz; Cseh, Edina Katalin; Kortesi, Tamas; Vereb, Daniel; Tomosi, Ferenc; Kecskemeti, Gabor; Janaky, Tamas; Tajti, Janos; Vecsei, Laszlo.
Altered glutamatergic neurotransmission and neuropeptide levels play a central role in migraine pathomechanism. Previously, we confirmed that kynurenic acid, an endogenous glutamatergic antagonist, was able to decrease the expression of pituitary adenylate cyclase-activating polypeptide 1-38, a neuropeptide with known migraine-inducing properties. Hence, our aim was to reveal the role of the peripheral kynurenine pathway in episodic migraineurs. We focused on the complete tryptophan catabolism, which comprises the serotonin and melatonin routes in addition to kynurenine metabolites. We investigated the relationship between metabolic alterations and clin. characteristics of migraine patients. Female migraine patients aged between 25 and 50 years (n = 50) and healthy control subjects (n = 34) participated in this study. Blood samples were collected from the cubital veins of subjects (during both the interictalictal periods in migraineurs, n = 47/12, resp.). 12 metabolites of Trp pathway were determined by neurochem. measurements (UHPLC-MS/MS). Plasma concentrations of the most Trp metabolites were remarkably decreased in the interictal period of migraineurs compared to healthy control subjects, especially in the migraine without aura subgroup Trp (p 〈 0.025), L-kynurenine (p /0.001), kynurenic acid (p / 0.016), anthranilic acid (p / 0.007), picolinic acid (p / 0.03), 5-hydroxy-indoleaceticacid (p / 0.025) and melatonin (p / 0.023). Several metabolites showed a tendency to elevate during the ictal phase, but this was significant only in the cases of anthranilic acid, 5-hydroxy-indoleaceticacid and melatonin in MWoA patients. In the same subgroup, higher interictal kynurenic acid levels were identified in patients whose headache was severe and not related to their menstruation cycle. Neg. linear correlation was detected between the interictal levels of xanthurenic acid/melatonin and attack frequency. Pos. associations were found between the ictal 3-hydroxykynurenine levels and the beginning of attacks, just as between ictal picolinic acid levels and last attack before ictal sampling. Our results suggest that there is a widespread metabolic imbalance in migraineurs, which manifests in a completely depressed peripheral Trp catabolism during the interictal period. It might act as trigger for the migraine attack, contributing to glutamate excess induced neurotoxicity and generalised hyperexcitability. This data can draw attention to the clin. relevance of KP in migraine.
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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”