Clark, Peter R. published the artcileCopper-catalysed C-H functionalisation gives access to 2-aminobenzimidazoles, Category: copper-catalyst, the publication is Organic & Biomolecular Chemistry (2019), 17(34), 7943-7955, database is CAplus and MEDLINE.
The development, optimization and exemplification of a copper-catalyzed C-H functionalization to form pharmaceutically relevant 2-aminobenzimidazoles from aryl-guanidines. High throughput screening was used as a tool to identify a catalytically active copper source, DoE was used for reaction optimization and a range of aryl-guanidines were prepared and exposed to the optimum conditions to afford a range of 2-aminobenzimidazoles in moderate to good yields. The methodol. was applied to the synthesis of Emedastine, a marketed anti-histamine pharmaceutical compound, with the key cyclization step performed on a gram-scale.
Organic & Biomolecular Chemistry published new progress about 14284-06-1. 14284-06-1 belongs to copper-catalyst, auxiliary class Copper, name is Copper(II) ethylacetoacetate, and the molecular formula is 0, Category: copper-catalyst.
Referemce:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660968/,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”