In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Kinetics of degradation of imidapril hydrochloride in finished dosage formulations, published in 2013-08-31, which mentions a compound: 89396-94-1, mainly applied to imidapril hydrochloride tablet stability degradability HPLC, Category: copper-catalyst.
This study investigates the impact of relative air humidity and temperature on the stability of imidapril hydrochloride (IMD) tablets. For this purpose the forced degradation test was used and the following environmental conditions were employed: RH = 76.4% and the temperature range of 313 – 333 K. For the determination of IMD content in the analyzed samples a reversed-phase high performance liquid chromatog. (RP-HPLC) technique was used. Three series of tablets were prepared: whole-blistered tablets, whole-bare tablets and halved-bare tablets, in order to analyze the influence of different in-home storage habits on IMD tablets’ quality. In the course of the study, the degradation of IMD was observed in each series of tablets. The kinetic mechanisms and the thermodn. parameters of these reactions were established. It was evidenced that halved IMD tablets stored without immediate packaging retain their quality only for 12 days while tablets stored according to label recommendations are stable for 513 days.
《Kinetics of degradation of imidapril hydrochloride in finished dosage formulations》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride)Category: copper-catalyst.
Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”