Deng, Zicheng; Lin, Jou; Bud’ko, Sergey L.; Webster, Brent; Kalin, Tanya V.; Kalinichenko, Vladimir V.; Shi, Donglu published their research in Cancers in 2021. The article was titled 《Dual Targeting with Cell Surface Electrical Charge and Folic Acid via Superparamagnetic Fe3O4@Cu2-xS for Photothermal Cancer Cell Killing》.Product Details of 13395-16-9 The article contains the following contents:
A major challenge in cancer therapy is to achieve high cell targeting specificity for the highest therapeutic efficacy. Two major approaches have been shown to be quite effective, namely, (1) bio-marker mediated cell targeting, and (2) elec. charge driven cell binding. The former utilizes the tumor-specific moieties on nano carrier surfaces for active targeting, while the latter relies on nanoparticles binding onto the cancer cell surfaces due to differences in elec. charge. Cancer cells are known for their hallmark metabolic pattern: high rates of glycolysis that lead to neg. charged cell surfaces. In this study, the nanoparticles of Fe3O4@Cu2-xS were rendered pos. charged by conjugating their surfaces with different functional groups for strong electrostatic binding onto the neg.-charged cancer cells. In addition to the pos. charged surfaces, the Fe3O4@Cu2-xS nanoparticles were also modified with folic acid (FA) for biomarker-based cell targeting. The dual-targeting approach synergistically utilizes the effectiveness of both charge- and biomarker-based cell binding for enhanced cell targeting. Further, these superparamagnetic Fe3O4@Cu2-xS nanoparticles exhibit much stronger IR absorptions compared to Fe3O4, therefore much more effective in photothermal therapy. The experimental process involved the reaction of Bis(acetylacetone)copper(cas: 13395-16-9Product Details of 13395-16-9)
Bis(acetylacetone)copper(cas: 13395-16-9) is used as PVC stabilizer, and curing agents for epoxy resins, acrylic adhesives and silicone rubbers. It is also used as solvents, lubricant additives, paint drier, and pesticides.Product Details of 13395-16-9
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”