HPLC of Formula: 492-27-3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-Hydroxyquinoline-2-carboxylic Acid, is researched, Molecular C10H7NO3, CAS is 492-27-3, about Vitamin C and E Treatment Blocks Changes in Kynurenine Metabolism Triggered by Three Weeks of Sprint Interval Training in Recreationally Active Elderly Humans. Author is Wyckelsma, Victoria L.; Trepci, Ada; Schwieler, Lilly; Venckunas, Tomas; Brazaitis, Marius; Kamandulis, Sigitas; Paulauskas, Henrikas; Gapeyeva, Helena; Paeaesuke, Mati; Gastaldello, Stefano; Imbeault, Sophie; Westerblad, Haakan; Erhardt, Sophie; Andersson, Daniel C..
The kynurenine pathway (KP) is gaining attention in several clin. fields. Recent studies show that phys. exercise offers a therapeutic way to improve ratios of neurotoxic to neuroprotective KP metabolites. Antioxidant supplementation can blunt beneficial responses to phys. exercise. We here studied the effects of endurance training in the form of sprint interval training (SIT; three sessions of 4-6 x 30 s cycling sprints per wk for three weeks) in elderly (~65 years) men exposed to either placebo (n = 9) or the antioxidants vitamin C (1 g/day) and E (235 mg/day) (n = 11). Blood samples and muscle biopsies were taken under resting conditions in association with the first (untrained state) and last (trained state) SIT sessions. In the placebo group, the blood plasma level of the neurotoxic quinolinic acid was lower (~30%) and the neuroprotective kynurenic acid to quinolinic acid ratio was higher (~50%) in the trained than in the untrained state. Moreover, muscle biopsies showed a training-induced increase in kynurenine aminotransferase (KAT) III in the placebo group. All these training effects were absent in the vitamin-treated group. In conclusion, KP metabolism was shifted towards neuroprotection after three weeks of SIT in elderly men and this shift was blocked by antioxidant treatment.
In addition to the literature in the link below, there is a lot of literature about this compound(4-Hydroxyquinoline-2-carboxylic Acid)HPLC of Formula: 492-27-3, illustrating the importance and wide applicability of this compound(492-27-3).
Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”