Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 492-27-3, is researched, Molecular C10H7NO3, about Bupi Yishen formula attenuates kidney injury in 5/6 nephrectomized rats via the tryptophan-kynurenic acid-aryl hydrocarbon receptor pathway, the main research direction is Bupi Yishen nephrectomized kidney tryptophan kynurenic acid receptor pathway; Aryl hydrocarbon receptor pathway; Bupi Yishen formula; Chronic kidney disease; Kynurenic acid; Metabolomics.Electric Literature of C10H7NO3.
Bupi Yishen Formula (BYF), a patent traditional Chinese medicine (TCM) formulation, has been used in the clin. treatment of chronic kidney disease (CKD). However, the mechanism of action of BYF has not been fully elucidated. To investigate the variation in the metabolic profile in response to BYF treatment in a rat model of 5/6 nephrectomy (Nx), rats in the treatment groups received low- or high-dose BYF. At the end of the study, serum and kidney samples were collected for biochem., pathol., and western blotting anal. Metabolic changes in serum were analyzed by liquid chromatog.-tandem mass spectrometry. The results showed that BYF treatment could reduce kidney injury, inhibit inflammation and improve renal function in a dose-dependent manner. In total, 405 and 195 metabolites were identified in neg. and pos. ion modes, resp. Metabolic pathway enrichment anal. of differential metabolites based on the Kyoto Encyclopedia of Genes and Genomes database identified 35 metabolic pathways, 3 of which were related to tryptophan metabolism High-dose BYF reduced the level of kynurenic acid (KA) by more than 50%, while increasing melatonin 25-fold and indole-3-acetic acid twofold. Expression levels of aryl hydrocarbon receptor (AhR), Cyp1A1, and CyP1B1 were significantly reduced in the kidney tissue of rats with high-dose BYF, compared to 5/6 Nx rats. BYF has a reno-protective effect against 5/6 Nx-induced CKD, which may be mediated via inhibition of the tryptophan-KA-AhR pathway.
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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”