Copper-Catalyzed Dehydrogenative Amidation of Light Alkanes was written by Fuentes, M. Angeles;Gava, Riccardo;Saper, Noam I.;Romero, Erik A.;Caballero, Ana;Hartwig, John F.;Perez, Pedro J.. And the article was included in Angewandte Chemie, International Edition in 2021.HPLC of Formula: 14781-45-4 This article mentions the following:
The functionalization of C-H bonds in light alkanes, particularly to form C-N bonds, remains a challenge. The dehydrogenative coupling of amides with C1-C4 hydrocarbons to form N-alkyl amide products with tBuOOtBu as oxidant, and a copper complex of a phenanthroline-type ligand as catalyst was reported. The reactions occurred in good yields in benzene or supercritical carbon dioxide as solvents. This strategy allowed for the determination of the relative reactivity of these alkane C-H bonds toward this amination process and showed, in contrast to prior work with larger alkanes, that the reactivity correlated with bond dissociation energies. In the experiment, the researchers used many compounds, for example, copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4HPLC of Formula: 14781-45-4).
copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to the earth-abundant, inexpensive and low toxicity. These ligands enable the reaction promoted in mild condition. The reaction scope has also been greatly expanded, rendering this copper-based cross-coupling attractive for both academia and industry. HPLC of Formula: 14781-45-4
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”