Copper(II)-catalyzed selective CAr-H bond formylation: synthesis of dialdehyde aniline was written by Guo, Shiwei;Li, Yinghua;Fan, Weibin;Liu, Zhiqi;Huang, Deguang. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2022.Category: copper-catalyst This article mentions the following:
A simple and efficient method for the synthesis of dialdehyde aniline I [R = 2-Me, 3-F, 2-Ph, etc.] in good yields (up to 83%) was explored using Cu(OTf)2 as the catalyst, Selectfluor as the radical initiator, and DMSO as both the carbon and oxygen sources. Exptl. studies indicated that the reaction was achieved by the formylation of two CAr-H bonds, first at the para-position and then at the ortho-position. A possible mechanism was proposed, including the thermal homolysis of Selectfluor, the Cu(II)-facilitated formylation of the CAr-H bonds, and the hydrolysis of the amide under alk. conditions in air atm. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Category: copper-catalyst).
Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The evolution of transition metal catalysts has attained a stage of civilization that authorizes for an extensive scope of chemical bonds formation partners to be combined efficiently. The copper-mediated C-C, C-O, C-N, and C-S bond formation is a part of one oldest reaction, emphasizing the Ullmann cross-coupling reaction.Category: copper-catalyst
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”