Aromatic nucleophilic substitution: A case study of the interaction of a lithiated nitronyl nitroxide with polyfluorinated quinoline-N-oxides was written by Gurskaya, Larisa;Rybalova, Tatyana;Beregovaya, Irina;Zaytseva, Elena;Kazantsev, Maxim;Tretyakov, Evgeny. And the article was included in Journal of Fluorine Chemistry in 2020.Product Details of 14781-45-4 This article mentions the following:
A 4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl lithium derivative was found to react with 5,6,7,8-tetrafluoro- or 5,7,8-trifluoro-6-(trifluoromethyl)quinoline-N-oxides with the formation of products of aromatic nucleophilic substitution of the H atom at position 2 of the quinoline ring. The reaction regioselectivity is supported by the data of quantum-chem. calculations Mol. and crystal structures of the obtained nitronyl nitroxides were solved by monocrystal X-ray diffraction anal., and the nature of the radical was ascertained by ESR spectroscopy. Heterospin complexes of Cu(hfac)2 with the synthesized quinoline-substituted nitronyl nitroxides were prepared According to X-ray diffraction anal., seven-membered metallocycles are formed in the complexes owing to simultaneous coordination of the nitroxyl and N-oxide groups by the Cu atom. In the experiment, the researchers used many compounds, for example, copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4Product Details of 14781-45-4).
copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to low toxicity and inexpensive, earth-abundant. Copper nanoparticles can also catalyze the coupling reaction of phenols, thiols, xanthogenates, nitrogen-containing nucleophiles, selenium ruthenium nucleophiles and the like.Product Details of 14781-45-4
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”