Diastereo- and Enantioselective Inverse-Electron-Demand Diels-Alder Cycloaddition between 2-Pyrones and Acyclic Enol Ethers was written by Huang, Guanghao;Guillot, Regis;Kouklovsky, Cyrille;Maryasin, Boris;de la Torre, Aurelien. And the article was included in Angewandte Chemie, International Edition in 2022.Related Products of 34946-82-2 This article mentions the following:
A broadly applicable diastereo- and enantioselective inverse-electron-demand Diels-Alder reaction of 2-pyrones and acyclic enol ethers was reported herein. Using a copper(II)-BOX catalytic system, bridged bicyclic lactones were obtained in very high yields (up to 99% yield) and enantioselectivities (up to 99% ee) from diversely substituted 2-pyrones and acyclic enol ethers. Mechanistic experiments as well as DFT calculations indicated the occurrence of a stepwise mechanism. The synthetic potential of the bridged bicyclic lactones was showcased by the enantioselective synthesis of polyfunctional cyclohexenes and cyclohexadienes, as well as a carbasugar unit. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Related Products of 34946-82-2).
Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents has turned up as an exceedingly robust synthetic tool. The copper-mediated C-C, C-O, C-N, and C-S bond formation is a part of one oldest reaction, emphasizing the Ullmann cross-coupling reaction.Related Products of 34946-82-2
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”