Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, is researched, Molecular C20H28ClN3O6, CAS is 89396-94-1, about Effects of long-term administration of (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxoimidazolidine-4-carboxylic acid hydrochloride (TA-6366), a new angiotensin I converting enzyme (ACE) inhibitor, from the pre-hypertensive stage on morphological change and mechanical property related to sodium ion permeability in aorta of spontaneously hypertensive rats (SHRs).Electric Literature of C20H28ClN3O6.
Effects of TA-6366 (I) on morphol. change and mech. property related to sodium ion permeability in the aorta of spontaneously hypertensive rats (SHRs) were examined, as compared with those of enalapril and captopril. Ten-week oral administration of I (1 and 5 mg/kg/d) from 4 wk of age impeded aortic media-thickening together with a rise in blood pressure in SHRs. Concomitantly, aorta weights in both groups were markedly decreased. The higher dose of I almost fully suppressed the accelerated tension development induced by K+-free medium and decreased total sodium ion content in the aorta. These vascular effects of I were more prominent than those of enalapril and captopril at 5 mg/kg/d. The difference in potencies on the above vascular parameters between I and these drugs seemed to be mainly related to the difference in their antihypertensive activities. These results suggest that I has preventive effects against progression of vascular diseases, particularly atherosclerosis, accompanied with hypertension.
From this literature《Effects of long-term administration of (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxoimidazolidine-4-carboxylic acid hydrochloride (TA-6366), a new angiotensin I converting enzyme (ACE) inhibitor, from the pre-hypertensive stage on morphological change and mechanical property related to sodium ion permeability in aorta of spontaneously hypertensive rats (SHRs)》,we know some information about this compound(89396-94-1)Electric Literature of C20H28ClN3O6, but this is not all information, there are many literatures related to this compound(89396-94-1).
Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”