《Ultrasmall Alloy Nanozyme for Ultrasound- and Near-Infrared Light-Promoted Tumor Ablation》 was written by Jana, Deblin; Wang, Dongdong; Bindra, Anivind Kaur; Guo, Yi; Liu, Jiawei; Zhao, Yanli. Category: copper-catalystThis research focused onultrasmall alloy nanozyme ultrasound IR tumor ablation; alloy; chemodynamic therapy; nanozyme; photothermal therapy; ultrasound. The article conveys some information:
The therapeutic effect of chemodynamic therapy (CDT) is significantly restricted by the stern reaction conditions and slow reaction rate of the Fenton reaction (pH 3-4). Herein, we report an ultrasmall trimetallic (Pd, Cu, and Fe) alloy nanozyme (PCF-a NEs) possessing dynamic active-site synergism, thus exhibiting a cascade glutathione peroxidase and peroxidase (POD) mimicking activities in circumneutral pH. PCF-a NEs exhibit photothermally augmented POD property and high photothermal conversion efficiency (62%) for synergistic tumor cell apoptosis. In addition, ultrasound can also enhance the mass transfer at active catalytic sites of PCF-a NEs, in turn accelerating Fenton-like reaction for tumor-specific CDT. This work provides a strategy for engineering alloy nanozymes in a bioinspired way for the amplification of intratumor reactive oxygen species in response to external stimuli, demonstrating enhanced efficiency for the inhibition of tumor growth in vitro and in vivo. The results came from multiple reactions, including the reaction of Bis(acetylacetone)copper(cas: 13395-16-9Category: copper-catalyst)
Bis(acetylacetone)copper(cas: 13395-16-9) is used as PVC stabilizer, and curing agents for epoxy resins, acrylic adhesives and silicone rubbers. It is also used as solvents, lubricant additives, paint drier, and pesticides.Category: copper-catalyst
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”