Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-2-Bromosuccinic acid, is researched, Molecular C4H5BrO4, CAS is 20859-23-8, about Stereoselective synthesis of resorcylic acid lactone Cochliomycin B.Quality Control of (S)-2-Bromosuccinic acid.
The total synthesis of 14-membered resorcylic acid lactone, Cochliomycin B (I) has prescribed, in a convergent manner, from readily available starting materials, D-galactose, L-aspartic acid and Et acetoacetate. The key reactions involved in the synthesis are Julia-Kocienski olefination, E-selective Horner-Wadsworth-Emmons olefination and intramol. lactonization.
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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”