Category: copper-catalyst. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: [Ir(dtbbpy)(ppy)2]PF6, is researched, Molecular C40H40F6IrN4P, CAS is 676525-77-2, about Redox-Neutral α-Allylation of Amines by Combining Palladium Catalysis and Visible-Light Photoredox Catalysis. Author is Xuan, Jun; Zeng, Ting-Ting; Feng, Zhu-Jia; Deng, Qiao-Hui; Chen, Jia-Rong; Lu, Liang-Qiu; Xiao, Wen-Jing; Alper, Howard.
The α-allylation of amines was achieved by combining palladium catalysis and visible-light photoredox catalysis. In this dual catalytic process, the generation of allyl radicals from the corresponding π-allylpalladium intermediates was achieved without addnl. metal reducing reagents (redox-neutral). Various α-allylation products of amines were obtained in high yields through radical cross-coupling under mild reaction conditions. Moreover, the transformation was applied to the formal synthesis of a 8-oxoprotoberberine derivative, which shows potential anticancer properties.
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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”