A 3-(2-hydroxyphenyl)imidazo[5, 1-a]isoquinoline as Cu(II) sensor, its Cu(II) complex for selective detection of CN- ion and biological compatibility was written by Mahata, Satyajit;Dey, Souradeep;Mandal, Biman B.;Manivannan, Vadivelu. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2022.Related Products of 20427-59-2 This article mentions the following:
The heterocyclic probe 3-(2-hydroxyphenyl)imidazo[5, 1-a]isoquinoline (LH) has exhibited specific recognition of Cu2+ ion by forming a complex of formula [Cu(L)2], which in turn showed recognition for CN- ions in CH3CN/aqueous HEPES-buffer solution (5 mM, pH = 7.4, 6:4, volume/volume). The selective colorimetric and fluorescence response of LH towards Cu2+ was achieved over other competing metal ions. Change of color from colorless to yellowish green upon incremental addition of Cu2+ into LH solution can be easily observed with naked-eye. Emission intensity of LH was quenched in presence of Cu2+ ion due to chelation enhanced quenching (CHEQ) process. From Job′s plot and mass spectral anal. the binding stoichiometry was found to 2:1 between LH and Cu2+. Binding of the probe LH with Cu2+ ion can be reversed by sequestering Cu2+ ion using Na2EDTA solutions Red shift in UV-visible spectrum upon addition of Cu2+ ion into LH solution was a consequence of decrease in HOMO-LUMO energy gap. From life time decay curve the average fluorescence life time (τ) was found to be 3.8 ns for free LH whereas in presence of Cu2+ τ decreased to 2.4 ns. In addition, so formed [Cu(L)2] complex was able to detect cyanide ion over other anions through removal of copper from the complex, as insoluble [CuCN]x. Limit of detection of LH for Cu2+ and [Cu(L)2] for CN– were found to be 0.45 μM and 0.30 μM resp. Detection of Cu2+ and CN– were also performed in environmental real water samples. Based on the cytotoxic anal., 5 μM of LH was selected for determining its fluorescence attributes in cellular imaging in MDA-MB-231 and HDF cells. The cell images showed that intracellular Cu2+ and CN– can be detected using LH and [Cu(L)2] complex resp. In the experiment, the researchers used many compounds, for example, Cuprichydroxide (cas: 20427-59-2Related Products of 20427-59-2).
Cuprichydroxide (cas: 20427-59-2) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to the earth-abundant, low toxicity and inexpensive. Copper of different valence states can be used to catalyze the coupling reaction, especially the Ullmann coupling reaction. Related Products of 20427-59-2
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”