In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Advantages of brain penetrating inhibitors of kynurenine-3-monooxygenase for treatment of neurodegenerative diseases, published in 2021-01-15, which mentions a compound: 492-27-3, mainly applied to review brain penetrating inhibitor neurodegenerative disease KMO; Brain penetrance; Inhibitor; Kynurenine-3-monooxygenase; Neurodegenerative disease; Prodrug, SDS of cas: 492-27-3.
A review. Kynurenine-3-monooxygenase (KMO) is an important therapeutic target for several brain disorders that has been extensively studied in recent years. Potent inhibitors towards KMO have been developed and tested within different disease models, showing great therapeutic potential, especially in models of neurodegenerative disease. The inhibition of KMO reduces the production of downstream toxic kynurenine pathway metabolites and shifts the flux to the formation of the neuroprotectant kynurenic acid. However, the efficacy of KMO inhibitors in neurodegenerative disease has been limited by their poor brain permeability. Combined with virtual screening and prodrug strategies, a novel brain penetrating KMO inhibitor has been developed which dramatically decreases neurotoxic metabolites. This review highlights the importance of KMO as a drug target in neurol. disease and the benefits of brain permeable inhibitors in modulating kynurenine pathway metabolites in the central nervous system.
Here is just a brief introduction to this compound(492-27-3)SDS of cas: 492-27-3, more information about the compound(4-Hydroxyquinoline-2-carboxylic Acid) is in the article, you can click the link below.
Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”