COA of Formula: C20H28ClN3O6. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, is researched, Molecular C20H28ClN3O6, CAS is 89396-94-1, about Kinetics and mechanism of solid state imidapril hydrochloride degradation and its degradation impurities identification. Author is Regulska, Katarzyna; Stanisz, Beata.
A detailed stability testing of solid state imidapril hydrochloride (IMD) was performed and its degradation products were identified. The anal. was conducted according to ICH guidelines Q1A(R2). Pure IMD samples were exposed to stress conditions of elevated temperature and relative humidity (T = 363 K, RH = 76.4%) to accelerate degradation The regular loss of IMD content with time, and the formation of 2 degradation impurities were observed The appropriate reaction rate constants k (for IMD degradation and for the formation of product I and II) were calculated using Prout-Tompkins equation. The obtained degradation products were separated and identified by LC-MS technique. Based on the obtained m/z values, the masses and the structures of the formed degradation impurities were established. Also IMD degradation scheme was constructed. It was demonstrated that under the applied anal. conditions, IMD degradation follows an autocatalytic reaction model with the rate constant k = 4.764 × 10-6 s-1 and with the parallel formation of 2 degradation products: imidaprilat and the diketopiperazine derivative The obtained exptl. results are in agreement with IMD degradation pathways proposed theor.
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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”