Obstals, Fabian; Witzdam, Lena; Garay-Sarmiento, Manuela; Kostina, Nina Yu.; Quandt, Jonas; Rossaint, Rolf; Singh, Smriti; Grottke, Oliver; Rodriguez-Emmenegger, Cesar published an article in 2021. The article was titled 《Improving Hemocompatibility: How Can Smart Surfaces Direct Blood To Fight against Thrombi》, and you may find the article in ACS Applied Materials & Interfaces.Formula: Br2Cu The information in the text is summarized as follows:
Nature utilizes endothelium as a blood interface that perfectly controls hemostasis, preventing the uncontrolled formation of thrombi. The management of pos. and neg. feedback that finely tunes thrombosis and fibrinolysis is essential for human life, especially for patients who undergo extracorporeal circulation (ECC) after a severe respiratory or cardiac failure. The exposure of blood to a surface different from healthy endothelium inevitably initiates coagulation, drastically increasing the mortality rate by thromboembolic complications. In the present study, an ultrathin antifouling fibrinolytic coating capable of disintegrating thrombi in a self-regulated manner is reported. The coating system is composed of a polymer brush layer that can prevent any unspecific interaction with blood. The brushes are functionalized with a tissue plasminogen activator (tPA) to establish localized fibrinolysis that solely and exclusively is active when it is required. This interactive switching between the dormant and active state is realized through an amplification mechanism that increases (pos. feedback) or restores (neg. feedback) the activity of tPA depending on whether a thrombus is detected and captured or not. Thus, only a low surface d. of tPA is necessary to lyse real thrombi. Our work demonstrates the first report of a coating that self-regulates its fibrinolytic activity depending on the conditions of blood. In the part of experimental materials, we found many familiar compounds, such as Cupric bromide(cas: 7789-45-9Formula: Br2Cu)
Some reported applications of Cupric bromide(cas: 7789-45-9) are: catalyst in cross coupling reactions; co-catalyst in Sonogashira coupling; lewis acid in enantioselective addition of alkynes.Formula: Br2Cu
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”