Rosenberg, Douwe published the artcileChemotherapeutic nitroheterocycles, XXVI. 5-Nitro-2-thiazolylpyrazoles and 5-nitro-2-thiazolylisoxazoles from 1,3-dicarbonyl compounds of the nitrothiazole series, COA of Formula: 0, the publication is Justus Liebigs Annalen der Chemie (1976), 13-21, database is CAplus.
5-Nitro-2-thiazolecarbonyl chloride (I) reacted with copper chelates II (R = EtO, Me, Ph, 4-ClC6H4, 2-furyl, 2-thienyl) to give 65-99% 1,3-dicarbonyl compounds III with a 5-nitro-2-thiazolyl moiety. III (R = Me, Ph) reacted with substituted hydrazines or hydroxylamine H2NXH (X = NH, NMe, NCH2CH2OH, NPh, O) to give 26-96% the title pyrazoles IV and (or V) (X = NH or substituted NH) or isoxazoles IV and(or) V (X = O). Some III have good antimicrobial activity (no data), but are very toxic and corrosive to the skin.
Justus Liebigs Annalen der Chemie published new progress about 14284-06-1. 14284-06-1 belongs to copper-catalyst, auxiliary class Copper, name is Copper(II) ethylacetoacetate, and the molecular formula is 0, COA of Formula: 0.
Referemce:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660968/,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”