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Compounds of the structure STR1 wherein Z is oxygen or sulfur; R is (C1 -C2)alkoxy; phenoxy; benzyl; phenylthiomethyl; phenylthio; phenylthio monosubstituted in the 2-, 3- or 4-position with (C1 -C3)alkyl, phenyl, methoxy, chloro, fluoro or trifluoromethyl; phenylthio disubstituted in the 2,5- or 3,5- positions with methyl, methoxy, chloro, or fluoro; 2,3,5,6-tetrafluorophenylthio; 1- or 2-naphthylthio; (C2 -C6)alkylthio; or halo (bromo or chloro); and the pharmaceutically-acceptable salts thereof are useful in lowering the blood glucose levels of hyperglycemic mammals.
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Reference：
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”