So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Watanabe, Kiyoshi; Mito, Seiji; Asano, Yuzo; Hori, Masaki researched the compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride( cas:89396-94-1 ).Product Details of 89396-94-1.They published the article 《Photosensitivity studies of imidapril hydrochloride in guinea pigs》 about this compound( cas:89396-94-1 ) in Oyo Yakuri. Keywords: photosensitivity imidapril hydrochloride UV. We’ll tell you more about this compound (cas:89396-94-1).
Imidapril hydrochloride (imidapril) was examined for its phototoxicity and photosensitization potential in guinea pigs. In a first study, guinea pigs were treated orally with a single dose of 0.1, 1 or 10 mg/kg of imidapril, and then they were irradiated with long-wave UV light (UVA). No phototoxic reaction was observed at any dose of imidapril. In a second study, guinea pigs were sensitized by oral administration of 0.1, 1 or 10 mg/kg or imidapril and irradiated with UVA. No photosensitization reaction was observed at any sensitizing dose of imidapril. Therefore, it is concluded that imidapril has neither phototoxicity nor photosensitization potential in guinea pigs.
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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”